摘要
单胺氧化酶 (monoamineoxidase,MAO)是生物体内一种十分重要的酶 ,它在大脑和周围神经组织中催化一些生物体产生的胺 ,氧化脱氨产生过氧化氢 (H2 O2 ) .单胺氧化酶A和B基因的克隆清楚地证明了这些酶是由不同的多肽组成的 .单胺氧化酶A和B的基因定位于X染色体 (Xp11 2 3) ,都由 15个外显子组成 ,而且它们的内含子 外显子组织是完全一致的 .这些事实表明单胺氧化酶A和B的基因很可能从同一个祖先进化而来 .单胺氧化酶A和B具有不同的底物和抑制剂专一性 ,在生物神经递质代谢和行为方面具有不同的作用 .
Monoamine oxidase (MAO) catalyzes the oxidative deamination of a number of biogenic amines in the brain and peripheral tissues by the production of hydrogen peroxide(H 2O 2). The cloning of MAO A and B genes has demonstrated that the enzymes are made of different polypeptides. MAO A and B genes are located on the X chromosome (Xp11 23) and consist of 15 exons with identical intron exon organization, which suggests that they are derived from the same ancestral gene. MAO A and B exhibit distinct differences in the substrate selectivity and inhibitor sensitivity and play different role in the neurotrasmitter metabolism and behavior.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2000年第5期504-508,共5页
Progress In Biochemistry and Biophysics
