摘要
神经生长抑制因子 (neuronalgrowthinhibitoryfactor,GIF)又名金属硫蛋白 Ⅲ (metallothionein Ⅲ ,MT Ⅲ ) ,特异分布于中枢神经系统 (CNS) ,是神经系统中第一个被鉴定的具有神经元生长抑制功能的蛋白 .GIF一级序列、高级结构、金属结合特性类似于其他MTs,基因结构也与其他MTs高度同源 ,但表达调控途径相异 .GIF可能以其 β结构域的CPCP区 ,与脑组织提取物中的相关因子结合 ,进而表现其生物学功能 .
Neuronal growth inhibitory factor(GIF), a brain specific member of metallothionein family named metallothionein Ⅲ (MT Ⅲ), is first validated to be capable of inhibiting the growth of neuronal cell in nervous system. GIFs amino acid sequence, structure and metal binding properties are like other metallothioneins, and its gene shows strikingly high homology to other metallothionein encoding genes, but they adopt different gene regulation approaches. With its β domain CPCP loop, GIF may bind to some correlative factors that lie in brain extracts to display its specific physiological function. It is considered that GIF is markedly reduced in the brain of Alzheimers disease (AD) patients and in several other neurodegenerative disease.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2000年第5期488-492,共5页
Progress In Biochemistry and Biophysics
基金
九五国家重点科技攻关!(96 C0 2 0 1 0 9)
关键词
神经生长抑制因子
金属硫蛋白
结构
功能
AD
neuronal growth inhibitory factor(GIF), metallothioneins(MTs), function, Alzheimer's disease
