摘要
线粒体对胞浆钙信号调节作用的研究已经历较长时间 .近年 ,随着研究方法和技术的不断改进 ,发现在绝大多数生理条件下 ,线粒体都能参与胞内钙通信过程 .线粒体可感受其周围钙微区的存在从而摄取钙 ,又可以通过钠 钙交换和大分子孔道将钙释放出来 ,因此可以调节胞浆钙信号的时空特性 ,影响相关的细胞功能 .但是 ,由于技术上的局限性 ,目前的研究仍然存在模糊不清和自相矛盾之处 。
It had been a long time to study the effect of mitochondria in the regulation of cytosolic calcium signal. Recently, following the development of new method and technology, it is found that mitochondria plays an important role in calcium signaling. Mitochondria can sense the existence of surrounding calcium microdomains and uptake Ca 2+ . It can also release Ca 2+ through 2Na +/Ca 2+ exchanger and mitochondrial permeablize transition pore. Therefore, the time spatio characteristic of cytosolic calcium signal can be regulated and related cellular function can be affected by mitochondria. However, due to the limitation of technique used now, confused and contradictory results are often obtained and further exploration is needed.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2000年第5期483-488,共6页
Progress In Biochemistry and Biophysics
关键词
线粒体
钙自稳平衡
钙微区
钠-钙交换
钙信号
mitochondria, calcium homeostasis, calcium microdomain, Na +/Ca 2+ exchanger
