摘要
目的通过近10年文献初步探讨膝关节骨性关节炎(KOA)内服中药的用药规律。方法检索2002至2012年收录于维普中文科技期刊数据库、中国期刊全文数据库、万方数据库的中药内服治疗KOA的临床文献,筛选符合标准的文献,采用频数统计的方法统计中药内服治疗KOA的总体用药频次、药对频次。结果纳入研究文献共491篇,包括572味中药、23个药对,药物总使用频次为5120次,使用频次最高的前10位依次为牛膝、当归、白芍、甘草、熟地黄、杜仲、川芎、独活、威灵仙、黄芪;药对总使用频次为891次,使用频次最高的前10位依次为牛膝和杜仲、黄芪和当归、桃仁和红花、独活和桑寄生、川乌和草乌、牛膝和当归、白芍和甘草、麻黄和桂枝、乳香和没药、黄柏和苍术。结论近10年治疗KOA内服方的药物组成以补肝脾肾、祛风寒湿为主;药对以补益肝肾、强筋壮骨以及益气活血为主。
Objective To research the application laws of orally taken Chinese medicinal for knee osteoarthritis （KOA） according to the related literature in recent 10 years. Methods The clinical literature on KOA treated with orally taken Chinese medicinal was searched in VIP Chinese Science and Technology Periodical Database, China Academic Journal and Wanfang Da- tabase from 2002 to 2012. The standards-compliant articles were included and the total medication frequency and medicinal pair frequency were analyzed with frequency statistics. Results There were 491 articles, 572 Chinese medicinals and 23 medicinal pairs included. The total medication frequency was 5 120 and the top 10 medicinals were： Niuxi （Radix Achyranthis bidentatae） , Danggui （Radix Angelicae sinensis ） , Baishao （Radix Paeonlae alba ）, Gancao （Radix et Rhizoma Glycyrrhizae ） , Shudihuang （Radix Rehmanniae praeparata ）, Duzhong （Cortex Eucommiae ） , Chuanxiong （Rhizoma Chuanxiong ） , Duhuo （Radix Angelicae pubescentis ） , Weilingxian （Radix et Rhizoma Clematidis ） and Huangqi （Radix Astragali ）. The medicinal pair frequency was 891 and the top 10 pairs were： Niuxi-Duzhong, Huangqi-Danggui, Taoren （Semen Persicae）-Honghua （ Flos Carthami ） , Duhuo-Sangjisheng （ Herba Taxilli ）, Chuanwu （Radix Aconiti ）-Caowu （Radix Aconiti Kusnezo f f ii ）, Niuxi-Danggui, Baishao-Gancao, Mahuang （ Herba Ephedrae ）-Guizhi （Ramulus Cinnamomi ）, Ruxiang （Olibanurn）-Moyao （Myrrha） and Huangbai （Cortex Phellodendri Chinensis ）-Cangzhu （Rhizoma Atractylodis ）. Conclusion The orally taken Chinese medicinal for KOA in recent 10 years is mainly composed with liver-spleen-kidney-supplementing and wind-cold-damp- dispelling medicinal and the role of medicinal pair is commonly supplementing the liver and kidney, strengthening sinew and bone, boosting qi and quickening the blood.
出处
《中医杂志》
CSCD
北大核心
2013年第7期608-610,共3页
Journal of Traditional Chinese Medicine
基金
云南省科技厅自然科学资金应用基础研究计划项目(2011FZ266)
云南省教育厅科学研究基金项目(09C0149)
云南白药、云南中医学院中医药教育创新基金项目(YB2011Y13)
关键词
膝关节骨性关节炎
中药内服
药对
文献分析
knee osteoarthritis
orally taken Chinese medicinal
medicinal pair
literature analysis
