摘要
目的 :观察环孢素软胶囊 (以下简称环孢素 )应用于肾移植病人的疗效和不良反应。方法 :2 4例入选的肾移植病人 ,男性 15例 ,女性 9例 ,年龄34a±s 6a(18～ 6 5a)。给予环孢素 +硫唑嘌呤 +泼尼松三联用药 ,其中环孢素起始剂量 8mg·kg- 1·d- 1,以后依血浓度 ,肝、肾功能调整给药量 ,硫唑嘌呤为 50～ 70mg·d- 1,泼尼松于术后d3给 80mg·d- 1,以后递减至维持量。所有病人使用环孢素 ,时间最长为 15mo ,观察随访期 12mo± 2mo。结果 :2 4例中仅出现 2例不典型急性排斥反应 ,2例ALT轻度升高 ,8例出现震颤 ,2例出现齿龈增生 ,5例多毛。结论 :环孢素软胶囊对肾移植病人具有免疫抑制作用 ,肝毒性小。
AIM: To observe the effect and adverse reaction of ciclosporin used in kidney transplantation patients. METHODS: Twenty four (M 15, F 9; age 34 a± s 6 a) kidney transplantation patients were choosed to receive the drug. They were given ciclosporin plus azapurine and predinisone. The beginning dosage of ciclosporin was 8 mg·kg -1 ·d -1 , and adjusted according to patients blood concentration, kidney and liver function. The dosage of azapurine was 50～70 mg·d -1 , and predinisone's was 80 mg·d -1 at d 3 after operation, then was decreased to the maintaining dosage. All patients took ciclosporin, the longest time was 15 mo, and following up duration was 12 mo±2 mo. RESULTS: only two patients occurred atypically acute rejection, two patients ALT hightened, 8 patients tremble, 2 patients tooth gum proliferation, 5 patients polytrichia. CONCLUSION: the immunoinhibitory effect of ciclosporin is reliable, and liver toxicity is lighter obviously.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2000年第5期398-400,共3页
Chinese Journal of New Drugs and Clinical Remedies
