摘要
以二溴甲基苯(o,m,p)为原料,分别与2-巯基苯并咪唑环化合成相应的含硫苯并咪唑环蕃,实验发现二溴甲基取代位置对反应结果有很大影响,o-位取代很易生成[1:1]型环化产物,p-位取代则主要得到链状产物,m-位取代环化产物较复杂,但以[2:2]型环化产物为主.产物结构通过1H NMR,IR,HRMS进行了表征,并得到了1-3a的X射线单晶衍射晶体结构,对其晶体结构进行了分析.
The novel sulfur-containing benzimidazole cyclophanes were synthesized from bis（bromomethyl）benzene （o, m, p） and 2-benzimidazolinthion, respectively. The reaction showed that bromomethyl positions effected the aim compounds very much. It was easy for o-substituted to generate the [ 1：1] type cyclization product, p-Substituted obtained chain product, and m-substituted benzene pruduced the [2：2] type cyclization compound as main product. The lead compounds were characterized by 1H NMR, IR, HRMS, and the structure of 1-3a was determined by X-ray diffraction method.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2013年第3期643-647,共5页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21042002)
陕西省自然科学基金(No.2010JM2001)资助项目~~
关键词
苯并咪唑环蕃
合成
表征
晶体结构
benzimidazole cyclophane
synthesis
characterization
crystal structure
