摘要
目的:比较4％毛果芸香碱凝胶(pilocarpine gel,PG)和1％毛果芸香碱溶液(pilocarpine solution,PS)的降眼压效果及安全性。方法:20例(40只眼)高眼压症及早期原发性开角型青光眼患者,采用自身对照,分别比较PG(每晚一次)和PS(每天4次)对日间多次眼压的降眼压效应,分别比较二者连续4周用药对某一时点(10AM)的眼压、瞳孔及屈光度的影响,以及眼部副作用。结果:4％PG每晚1次用药,其有效降眼压时间可持续20小时,降眼压幅度达9.3％～13.8％,连续4周用药的10AM各时点的降眼压幅度为11.3％～17.6％;1％PS每天用药4次降眼压幅度达12.4％～16.2％,连续用药4周的10AM各时点降眼压幅度为17.4％～19.7％;二者差异无显著性意义。连续四周用药的10AM各时点的瞳孔缩小及近视屈光度增加,4％PG明显小于1％PS,应用4％PG亦很少主诉有视物模糊。结论:在降眼压效果方面,PG与PS相似;从用药方便性、患者依从性、对瞳孔及近视度的影响,PG较PS优越,值得推广作为临床替代PS多次用药的一种长效缓释药物剂型。眼科学报2000;16:77-80。
Purpose: To compare the efficacy and safety of 4% pilocarpine gel(PG) and 1% pilocarpine solution (PS).
Methods: Twenty cases(40 eyes) with ocular hypertension or primary open angle glaucoma (POAG) in early stage were treated by 4% PG(once per night) and PS (4 times per day) . We compared the side-effects and the changes in the intraocular pressure (IOP) , pupil size and diopter of 2 groups after medication. Self-control was chosen. Results: The effect of 4% PG on IOP can last 20 hours. The' IOP decreasing range of the PG group was from 9. 3% to 13. 8% , while the PS group was from 12. 4% to 16. 2% . The decreasing range at 10 AM for four weeks of the PG group was from 11. 3% to 17.6% while the PS group was from 17.4% to 19.7%. There is no statistically significant difference between two groups. There are more obvious changes in the pupil size and diopter in the PS group and less complain of blurred vision in the PG group. Conclusion: The IOP decreasing effect of 4% PG is comparable with that of 1 % PS, but the 4% PG is better than 1%PS as concerning the patient compliance and the side effects. So the 4% PG can be used as a substitute for the 1%PS in the clinic. Eye Science 2000; 16: 77 - 80.
出处
《眼科学报》
2000年第2期77-80,共4页
Eye Science
