摘要
目的:观察无创机械通气对急性左心衰竭的治疗作用及其对C反应蛋白(CRP)水平的影响。方法:将急性左心衰竭患者53例随机分为2组:常规组27例,给予高流量吸氧+药物治疗;无创通气组26例,给予经面罩双水平无创正压通气+药物治疗。观察两组患者治疗后的临床疗效以及CRP水平的变化,并进行相关分析。结果:无创通气组有效率96%,常规组有效率70%,无创通气组的临床疗效好于常规组(P<0.05)。治疗后24 h两组CRP水平较治疗前显著下降(P<0.01),且两组间的差异有统计学意义(P<0.01)。治疗后两组的收缩压(SBP)、舒张压(DBP)、心率(HR)、呼吸频率(RR)较治疗前明显降低(P<0.01),动脉氧分压(PaO_2)、血氧饱和度(SpO_2)较治疗前明显升高(P<0.01),治疗后1 h两组间的SBP、DBP、HR、RR、PaO_2、SpO_2比较,差异均有统计学意义(P<0.05或P<0.01),治疗后24 h两组间的PaO_2、SpO_2比较,差异有统计学意义(P<0.01)。结论:无创机械通气能够提高急性左心衰竭的治疗效果,并能够降低C反应蛋白水平。
AIM： To observe the therapeutic acute left ventricular failure and the changes effect of noninvasive mechanical ventilation on patients with of C-reactive protein （CRP）. METHODS： A total of 53 patients with acute left heart failure were randomly divided into two groups： conventional group of 27 patients treated with high-flow oxygen and routine drug therapy and noninvasive ventilation group of 26 cases treated with bi-level noninvasive positive pressure ventilation via face mask and routine drug therapy. Clinical efficacy and CRP levels in the two groups were assessed. RESULTS： The effective rates in noninvasive ventilation group and conventional group were, respectively, 96% and 70%, with statistically significant differences （P 〈0. 05）. Twenty-four hours after treatment, CRP levels were significantly lower than those before treatment （P 〈0. 01 ） and cant （ P 〈 0. 01 ）. After treatment, systolic heart rate （HR） and respiratory rate （RR） 0. 01 ） , whereas PaO2 and SpO2 increased （ cant difference was observed in SBP, DBP, HR, RR, PaO2 and SpO2 between conventional group and noninvasive ventilation group （P 〈 0. 01 or 0.05）. Twenty-four hours after treatment, a statistically significant difference was seen in PaO2 and SpO2 between groups （P 〈0. 01 ）. CONCLUSION： Noninvasive mechanical ventilation can improve the treatment efficacy in patients with acute left ventricular failure and reduce the level of CRP.
出处
《心脏杂志》
CAS
2013年第1期73-76,共4页
Chinese Heart Journal
关键词
无创机械通气
急性左心衰竭
C反应蛋白
noninvasive mechanical ventilation
acute left ventricular failure
C-reactive protein
