摘要
遗传因素影响机体对铅毒性的易感性。δ-氨基乙酰丙酸脱水酶(ALAD)基因、维生素D受体(VDR)基因、血色素基因(HFE)基因、基质γ-羧基谷氨酸蛋白(MGP)T-138C、X射线交错互不修复基因1(XRCC1)和X射线交错互不修复基因3(XRCC3)的不同基因多态性对铅中毒的易感性有一定影响。铅毒性基因的易感性研究将会为儿童铅中毒的易感人群筛选和铅中毒治疗提供遗传学的依据,以便及早识别易感者,尽早保护易感人群,防止或减少铅中毒的发生并采取针对性的健康教育宣传。
Genetic factors affect the susceptibility of lead toxicity. It has certain influence to the susceptibility of lead poisoning that is the different gene polymorphism of deha-aminolevulinate dehydratase （ALAD） gene, vita- min D receptor （VDR） gene, hemoglobin gene （HFE）, matrix-carboxyl glutamie acid protein （MGP） T-138C, X ray staggered no repair gene 1 （ XRCC1 ） and X ray staggered no repair gene 3 （ XRRC3 ）. The research of lead toxicity genetic susceptibility will provide the basis for the children lead poisoning at-risk group screening and lead poisoning treatments, in order to recognise and protect the susceptible person, prevent or reduce the occurrence of lead poisoning and take pertinent the health education propaganda.
出处
《新医学》
2013年第2期86-89,共4页
Journal of New Medicine
关键词
铅中毒
儿童
易感基因
Lead poisoning
Children
Susceptibility geue
