摘要
异位脂肪是引起胰岛素抵抗的重要原因,脂质异位沉积于肝脏、肌肉均与胰岛素抵抗密切相关。异位脂肪形成的原因目前尚不清楚,脂肪组织储脂能力下降、线粒体功能低下及组织内脂肪酸β氧化减少,脂肪炎症及内分泌学说,以及CD36在组织细胞膜中分布不同均可能导致异位脂肪沉积。炎症因子、内质网压力、脂质因子等在肝脏及骨骼肌的胰岛素抵抗形成中有重要作用,但是不发生于体质量正常的胰岛素抵抗的年轻人及老年人中。而二酰甘油所诱发的胰岛素抵抗可出现在肥胖、先天性脂肪营养不良、2型糖尿病的正常体质量的后代等人群,以及随着年龄的增加也可出现。
Ectopic fat is an important cause of insulin resistance. The cause for ectopic fat storage is largely unkown, failure of fat cell proliferation, mitochondrial function and fat oxidation, endocrine hypothesis, and altera- tions in CD36 content in adipose tissue, muscle, and presumably liver might all contribute to the association be- tween ectopic fat distribution and metabolic disease. Endoplasmicreticulum stress and adipokines have roles in the pathogenesis of insulin resistance in liver and skeletal muscle. However, these do not change in lean insulin-resist- ant young and elderly individuals. In muscle and liver, the intracellular accumulation of lipids-namely, diacylglyc- erol-triggers activation of novel protein kinases C with subsequent impairments in insulin signalling. This unifying hypothesis accounts for the mechanism of insulin resistance in obesity, type 2 diabetes, lipodystrophy, and ageing.
出处
《新医学》
2013年第2期79-81,共3页
Journal of New Medicine
关键词
异位脂肪
胰岛素抵抗
Ectopic fat
Insulin resistance
