摘要
从狼毒大戟中分得的两个二萜内酯化合物:16-hydroxypseudojolkinolide B(化合物Ⅰ)和 jolkino-lide B(化合物Ⅱ),对人红白血病K562细胞及人鼻咽癌CNE2细胞的抑制作用呈明显的量效关系,化合物Ⅰ的IC_(50)与阿霉素相当。
In this paper, two diterpenoide lactones 16-hydroxypseudojolkinolide B and jolkinolide B were isolated from Euphorbia fischeriana Steud. They showed inhibitory effect on human tumor cells both the K562 cell and CNE2 cell and significant dose-effect relationship. The IC50 values of 16-hydroxypseudojolkinolide B on the two human tumor cells were near to that of ADM's.
出处
《中药材》
CAS
CSCD
2000年第10期623-625,共3页
Journal of Chinese Medicinal Materials
基金
广东省中医药管理局基金(99539)
关键词
狼毒大戟
抗癌活性
癌细胞
阿霉素
体外抑制作用
Euphorbia fischeriana Steud
Diterpenoide lactones
Inhibitory tumor effect
Human tumor cells
ADM
