摘要
目的:观察泮托拉唑联合铝碳酸镁治疗胃食管反流病(GERD)的临床效果。方法:选择72例GERD患者随机分成治疗组及对照组,每组36例。治疗组予以泮托拉唑联合铝碳酸镁口服,对照组单独予以泮托拉唑口服,6个月为1疗程。治疗后4周及8周观察两组症状改善情况,治疗8周后复查胃镜观察胃镜下疗效。结果:治疗组治疗4周及8周后症状改善总有效率分别为88.9%及97.2%,显著优于对照组的75.0%及86.1%,差异显著(P<0.05);治疗组治疗8周后胃镜检查总有效率为97.2%,显著优于对照组的80.6%,差异显著(P<0.05);两组均无严重不良反应。结论:泮托拉唑联台铝碳酸镁治疗胃食管反流病安全有效,适合临床推广。
Objective：Observation of pantoprazole combined with hydrotalcite in treatment of gastroesophageal reflux disease（GERD） clinical effect.Methods：72 cases of GERD patients were randomly divided into treatment group and control group,36 cases in each group.Treatment group received pantoprazole combined with hydrotalcite oral,controls individually give pantoprazole oral,6months for 1courses.After 4 weeks of treatment and8 weeks on two groups of symptoms,treatment and 8 weeks after the gastroscope gastroscopic curative effect observation.Results：the treatment group 4 and 8 weeks after the symptoms improve the total efficiency of respectively 88.9% and 97.2%,significantly higher than that of the control group of 75% and 86.1%,significant difference（P0.05）;the treatment group after 8 weeks treatment gastroscopy the total efficiency was 97.2%,significantly higher than that of the control group was 80.6%,significantly（P0.05）;the two groups were no serious adverse reaction.Conclusion：pantoprazole combined hydrotalcite in treatment of gastroesophageal reflux disease is safe and effective,suitable for clinical application.
出处
《中国医药导刊》
2013年第2期283-284,共2页
Chinese Journal of Medicinal Guide
关键词
胃食管返流病
泮托拉唑
铝碳酸镁
Gastroesophageal reflux disease
Pantoprazole
Hydrotalcite
