摘要
目的:探讨微生态制剂对婴幼儿抗菌药相关性腹泻(AAD)的预防作用。方法:360例因肺炎住院的婴幼儿随机分为2组,治疗组172例,在使用抗菌药的同时口服微生态制剂(酪酸梭菌糖化菌肠球菌活菌制剂),100 mg,tid;对照组188例,仅使用抗菌药,不使用微生态制剂。两组患儿均给予相同的对症治疗,比较两组AAD发生率及腹泻病程。结果:治疗组有15例(8.72%)患儿发生AAD,对照组有49例(26.06%)发生AAD,两组发生率差异有统计学意义(P<0.05);治疗组AAD患儿腹泻持续时间(3.62±1.53)d,明显低于对照组持续时间(6.45±1.98)d(P<0.05)。结论:微生态制剂能有效预防婴幼儿AAD。
Objective：To investigate the preventive effect of microecologic preparations on antibiotic-associated diarrhea in infants. Method：Three hundred and sixty hospitalized inlants with pneumonia were randomly divided into two groups,the therapy group and the control group.The treatment protocol for 172 cases in the therapy group was oral 300mg/d microecologic preparations and antibiotics, while that for 188 cases in the control group was antibiotics alone.The same symptomatic treatment was applied in the two groups.The incidence of antibiotic-associated diarrhea and the diarrhea duration were compared between the two groups.Result：The incidence of antibiotic-associated diarrheain in the therapy group（8.72%） was significantly lower than that in the control group （26.06%,P 0.05）.The diarrhea duration in the therapy group[（3.62±1.53）d]was significantly shorter than that in the control group（[（6.45±1.98）d,P0.05）.Conclusion：Microecologic preparations can effectively prevent antibiotic-associated diarrhea in infants.
出处
《中国药师》
CAS
2013年第3期420-421,共2页
China Pharmacist
关键词
微生态制剂
抗菌药相关性腹泻
婴幼儿
预防
Microecologic preparations
Antibiotic-associated diarrhea
Infant
Prevention
