摘要
目的:评价国产注射用头孢他啶与国产注射用头孢唑肟治疗呼吸系统细菌性感染的有效性和安全性。方法:采用区组随机化、平行对照、单盲试验。142例呼吸科住院患者随机分成两组,观察组用头孢他啶治疗,对照组用头孢唑肟治疗,给药方案均为2 g溶于0.9%氯化钠注射液100 ml,20～30 min内ivd,q12h。评价两组临床疗效和安全性。结果:可进行临床疗效评价的共136例,观察组和对照组各68例;可进行安全性评价138例,观察组70例,对照组68例。观察组和对照组临床有效率分别为91.17%(62/68)和89.71%(61/68),药物不良反应发生率分别为5.7%(4/70)和2.9%(2/68),两组比较差异均无统计学意义(P>0.05)。结论:注射用头孢他啶在治疗呼吸系统细菌感染性疾病的有效性与安全性与头孢唑肟相当。
Objective：To evaluate the efficacy and safety of ceftazidime and ceftizoxime injections in the treatment of acute lowgrade, moderate and severe respiratory tract infections.Method：By single-blind and parallelism randomized clinical study,142 patients from June in 2010 to May in 2011 were randomly divided into two groups（ceftazidime in the treatment group and ceftizoxime in the control group）.The dose was 2g dissolved in 100ml 0.9%NaCl solution with ivd in 20-30min,bid and the course of 7-10d.Result： Totally 136 patients were evaluated in the efficacy（68 in the treatment group and 68 in the control group）,and 138 patients were evaluated the safety（70 in the treatment group and 68 in the control group）.Effective rate and incidence of side effects were 91.17% （62/68） and 5.7%（4/70） in the treatment group,and 89.71%（61/68） and 2.9%（2/68） in the control group.There was no statistically significant difference between the two groups.Conclusion：Ceftazidime injections are as effective and safe in the treatment of acute respiratory bacterial infections as ceftizoxime injections.
出处
《中国药师》
CAS
2013年第3期406-408,共3页
China Pharmacist
