摘要
目的 :探讨脉络宁对重型肝炎患者血小板活性的影响。方法 :采用ELISA法和单克隆酶联免疫吸附法 ,检测了 51例慢性重型肝炎患者和 4 4例健康体检者的血浆内血小板α颗粒膜蛋白 (GMP 1 4 0 )和血管性假血友病因子相关抗原 (vWF∶Ag)含量。 51例慢性重型肝炎患者 ,随机分为两组 :一般治疗组和脉络宁治疗组 (在一般治疗基础上加用脉络宁 ) ,疗程两周。结果 :慢性重型肝炎患者血浆GMP 1 4 0、vWF∶Ag含量均明显高于正常对照组 (P <0 .0 1 )。脉络宁治疗组用药两周后 ,血浆GMP 1 4 0、vWF∶Ag水平均明显下降 (P <0 .0 1 )。结论 :慢性重型肝炎患者血小板处于明显活化状态 ,脉络宁对该病患者的血小板活性具有明显抑制作用。
OBJECTIVE:To investigate the effect of Mailuoning on platelet activity in the patients with chronic severe viral hepatitis(CSVH).METHODS:The levels of granule membrane protein 140(GMP 140) and von winebrand factor antigen(vWF∶Ag) in the plasma of 51 patients with CSVH and 46 healthy individuals as control were detected with ELISA and monoclonal enzyme linked immunosorbent adsorption assay.51 patients with CSVH were randomly divided into two groups:general treatment group and Mailuoning group(general treatment plus Mailuoning).After two weeks medication,the same observation items were detected again.RESULTS:The levels of GMP 140 and vWF∶Ag in the plasma of the patients with CSVH were significantly higher than those of the normal controls(P<0.01).The levels of GMP 140 and vWF∶Ag in the plasma of the patients with CSVH significantly decreased(P<0.01) after treatment with Mailuoning for 2 weeks.CONCLUSION:The platelet activity was elevated in the patients with CSVH.Mailuoning could significantly inhibit the platelet activity in CSVH.
出处
《中国现代应用药学》
CAS
CSCD
2000年第5期404-406,共3页
Chinese Journal of Modern Applied Pharmacy
