摘要
目的 了解麻醉与手术对肾小球和肾小管功能的影响。方法 病人分为 4组 :1、全身麻醉 +较大手术组 (G +B) ;2、全身麻醉 +较小手术组 (G +S) ;3、硬膜外阻滞 +较大手术组 (E +B) ;4、硬膜外阻滞 +较小手术组 (E +S)。每组 10例。检测术前、术中 1h和术后 2 4h尿中 β2 微球蛋白 (β2 MG)、白蛋白 (Alb)和免疫球蛋白G(IgG)浓度。结果 在不同麻醉方法下行较小手术时 ,术中及术后尿中 β2 MG、Alb、IgG无显著性变化 (P >0 0 5 ) ,而较大手术两组病人的术中及术后尿中β2 MG、Alb、IgG浓度明显升高 (P <0 0 5 ) ,个别病人呈尿蛋白阳性。结论 围术期肾小球和肾小管功能与麻醉的关系较小 。
Objective To investigate the effects of anesthesia and operation on glomerular and renal tubular function Methods Forty patients without renal disease were assigned to 4 groups: general anesthesia + minor operation; general anesthesia +major operation; epidural block + minor operation and epidural block + major operation The concentration of β_2-microglobulin(β_2-MG)、albumin(Alb)and immunoglobulin G(IgG)in urine were measured before operation ,1h following operation and 24h after operationResults In the groups of major operation, the concentrations of β_2-MG, Alb and IgG in urine increased significantly during and after operation(P<005), but without significant changes in the groups of minor operation(P>005)Conclusions The influences on renal glomerular and tubular function during perioperation are related to the degree of operative stimulation, but do not to the anesthesia
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2000年第10期597-599,共3页
Chinese Journal of Anesthesiology
关键词
全身麻醉
硬膜外麻醉
外科手术
肾小球
肾小管
Anesthesia,general
Anesthesia,epidural
Surgical procedures,operative
Kidney tubules
Kidney glomerulus
