摘要
分析Ⅱ型糖尿病患者血浆抗氧化维生素A、E ,抗氧化酶SOD活性和一氧化氮 (NO)含量变化 ,以探讨氧化和抗氧化系统与糖尿病的关系。测定 33例Ⅱ型糖尿病患者 (男 /女15 :18,年龄 5 6 1± 11 1岁 )血浆抗氧化维生素A、E水平 ,抗氧化酶SOD活性和NO含量 ,并与 33例正常对照 (男 /女 16∶17,年龄 5 6 0± 10 5岁 )进行比较。结果发现 ,糖尿病组与对照组相比 ,血浆抗氧化维生素A、E水平无显著性差异 ;SOD活性显著降低 (P <0 0 5 ) ;糖尿病组的血浆NO水平比正常对照组的显著增高 (P <0 0 1)。提示糖尿病患者抗氧化系统失衡 。
To in estigate the levels of plasma antioxidant in patients with type Ⅱ diabetes mellitus,and to examine the relationship between plasma antioxidant levels and the development of complications in diabetes.A total of 33 patients with type Ⅱ diabetes mellitus(M/F 15/18,age 56 1±11 1 years)and 33 control subjects(M/F 16/17,age 56 0±10 5 years)were involved in the study.The levels of plasma antioxidants including vitamin A, vitamin E,enzyme superoxide dismutase(SOD) activity and the contents of nitric oxide(NO)were measured.Compared with age,sex matched control subjects,no significant changes of plasma antioxidant vitamin A,E levels in patients with type Ⅱ diabetes mellitus were observed.The activity of SOD was reduced (P<0 05) and the content of NO was increased(P<0 01) in patients with diabetes as compared with controls.The results suggested tht an impaired antioxidant system might play a role in the pathogenesis of diabetes mellitus.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2000年第10期880-882,共3页
Chinese Journal of Public Health
基金
中华医学基金 (CMB)资助课题
