摘要
目的研究降低血小板预防性输注阈值对特发性血小板减少性紫癜患者的影响。方法随机选择2006年3月-2012年3月在血液科诊断的ITP(特发性血小板减少性紫癜)住院患者,将符合ITP诊断标准的272例按住院号进行随机分组,住院号为单数的作为传统组,将血小板小于20×109/L作为血小板预防性输注阈值,住院号为双数的作为研究组,将血小板小于10×109/L作为血小板预防性输注阈值。分别比较两组二级(WHO分级)或二级以上出血率、不良反应发生率及血小板输注率。结果将研究组与传统组二级或二级以上出血率作比较,两组差异均无统计学意义(P均>0.05),而不良反应发生率及血小板输注率比较两组差异有统计学意义(P<0.05)。结论降低血小板预防性输注阈值对特发性血小板减少性紫癜患者出血风险无显著影响,但能减少血小板输注率及不良反应发生率。
Objective To investigate of impact of reducing platelet prophylactic transfusion threshold on idiopathic thrombocytopenic purpura patients.Methods From March 2006 to March 2012,272 hospitalized patients in the hematology diagnosed as ITP（Idiopathic thrombocytopenic purpura） were randomly selected,patients were divided according to hospital No.Hospitalization number as singular as the traditional group,platelets less than 20×109/L as a prophylactic platelets threshold,hospitalization number with even number as the study group,platelets less than 10×109/L as a prophylactic platelets threshold.Bleeding rate and the incidence of adverse reactions and platelet infusion rate between the two groups two（WHO classification）or above grade two were compared.Finally the statistical analysis was conducted.Results Comparison of two or two more bleeding rate for the corresponding level between the study group and conventional group,there were no significant differences（P0.05）,while the incidence of adverse reactions and platelet infusion rates were compared between the two groups had significant difference（P0.05）.Conclusion Decreased platelet prophylactic transfusion threshold on idiopathic thrombocytopenic purpura in patients had no significant effect on bleeding risks,but can reduce platelet infusion rate and the incidence of adverse reactions.
出处
《中华全科医学》
2013年第3期390-391,共2页
Chinese Journal of General Practice
关键词
血小板
阈值
预防性输注
出血
Platelet
Threshold
Prophylactic infusion
Bleeding
