摘要
背景:治疗脊髓损伤的人工合成高分子支架材料是目前的研究热点之一。目的:综述国内外人工合成高分子支架材料在治疗脊髓损伤方面的研究进展。方法:应用计算机检索万方医学、中国知网、PubMed、EBSCO数据库中2000年1月至2012年1月关于人工合成高分子支架材料治疗脊髓损伤方面的文章,在标题和摘要中以"脊髓损伤,组织工程,人工合成高分子材料"或"spinal cord injury,tissue engineering,synthetic polymer material"为检索词进行检索。结果与结论:治疗脊髓损伤的人工合成高分子材料很多,主要有聚乳酸、聚羟基酸、聚β-羟丁酸、合成水凝胶、聚乙二醇及其他人工合成高分子材料。每种材料都有其优缺点,都无法达到完全的组织相容性和可降解性,这些支架材料不能完全模仿脊髓的三维多孔立体结构,移植后这些支架材料的位置相对于脊髓结构来讲是随机的,并未与脊髓的灰、白质组织学结构吻合,更没有和白质中主要纤维相对应,所以均未应用于临床。人工合成高分子支架材料在治疗脊髓损伤方面需要进一步研究。
BACKGROUND： Synthetic polymer scaffolds for treatment of spinal cord injury are currently a focus of research.OBJECTIVE： To summarize domestic and foreign researches on synthetic polymer scaffolds for the treatment of spinal cord injury.METHODS： Articles on synthetic polymer scaffolds for treatment of spinal cord injury were searched on WanfangMed, CNKI, PubMed and EBSCO databases from 2000-01 to 2012-01, using ＂spinal cord injury,tissue engineering, synthetic polymer material＂ appearing in title/abstract as key words.RESULTS AND CONCLUSION： Many kinds of synthetic polymer materials are developed for the treatment of spinal cord injury, including polylactic acid, polyglycolic acid, poly-13 hydroxybutyric acid, synthetic hydrogel, and polyethylene glycol. Each material has its pros and cons, but none has complete tissue compatibility and biodegradability. These materials cannot completely mimic the three-dimensional porous structure of the spinal cord. After implantation, the materials are located freely to the spinal cord, which cannot be anatomized with the gray and white matters of the spinal cord, and fatherly cannot correspond to the main fibers in the white matter. Therefore, these materials have not been implemented in clinical trial. Further study on synthetic polymer scaffolds for the treatment of spinal cord injury is required.
出处
《中国组织工程研究》
CAS
CSCD
2013年第3期501-508,共8页
Chinese Journal of Tissue Engineering Research
关键词
生物材料
生物材料综述
脊髓损伤
组织工程
人工合成高分子材料
聚乳酸
聚羟基酸
聚β-羟丁酸
合成水凝胶
聚乙二醇
biomaterials
biomaterial review
spinal cord injuries
tissue engineering
synthetic polymer materials
polylactic acid
polyglycolic acid
poly-beta-hydroxybutyric acid
synthetic hydrogel
polyethylene glycol
