摘要
为观察 4℃冷甘露醇对高热和超高热的降温效果 ,并探讨其降温机理 ,将 179例高热和超高热患者分为治疗组和对照组 ,对其降温进行随机单盲对照观察。显示高热治疗组显效 ( 1h内降温 )占 81 13% ,有效 ( 2h内降温 )占 18 87% ,总有效率 10 0 % ,显著优于对照组 (P <0 0 0 1)。超高热治疗组显效 75% ,有效 2 5% ,总有效率 10 0 % ,优于对照组 (P <0 0 5)。说明 4℃冷甘露醇对高热和超高热的降温效果肯定 ,方法简便 ,无毒副作用 ,降温同时能解除脑水肿 ,打断高热与脑水肿之间的恶性循环。其降温机理可能是 :⑴直接降低血温 ;⑵高渗性利尿排出部分热量 ;⑶解除脑水肿 ,抑制中枢性高热 ;⑷清除自由基 ,有利于机体的康复。
The effect of reducing the temperature of patients with high fever and overhigh fever by infusing 4℃ mannitol and its mechanism were studied,179 patients with high fever and overhigh fever were divided into treated group and control group.Hypothermic effects were observed by a randomized single blind method.The results showed that 81 13% of the high fever treated group was greatly improved (temperature reduced within an hour),and 18 87% was improved(temperature reduced within two hours).The total response rate was 100%.The treated group was obviously superior to the control group(P<0 001).75% of the overhigh fever in treated group was greatly improved and 25%,effectual.The total response rate was 100%.The effectiveness in treated group were better than that in control group(P<0 05).We conclude that the advantages of the therapy are simple and convenient,and no adverse reactions.At the same time,brain edema can be eliminated while temperature is being reduced,and malignant cycle between high fever and brain edema can be cut off.The mechanism may be:⑴To directly reduce the blood temperature;⑵Part of the heat is driven out by hyperosmotic diuresis;⑶To eliminate brain edema and inhibit central high fever;⑷To eliminate·OH -,it is beneficial to body recovery.
出处
《中国医师杂志》
CAS
2000年第9期528-529,共2页
Journal of Chinese Physician
