摘要
目的探讨肺外周性肿瘤的超声造影表现与微血管密度（MVD）的关系。方法利用超声造影研究经病理证实的55例肺外周性肿瘤患者，其中恶性肿瘤40例，良性肿瘤15例，应用时间．强度曲线分析软件分析定量参数（峰值强度和增强强度指数），术后应用免疫组织化学方法测量肿瘤MVD，分析两者相关性。结果恶性肿瘤MVD明显大于良性肿瘤[（24．57±5．93）个PAP比（15．50±2．82）个PAP]，差异有统计学意义（P〈0．05）；MVD与超声造影的定量参数（峰值强度和增强强度指数）呈显著正相关（P〈0．01）。结论超声造影的定量参数与MVD有显著相关性，可作为定量评价肿瘤血管生成的依据。
Objective To observe the correlation between contrast-enhanced sonography and microvessel density （MVD） in peripheral lung tumor. Methods Contrast-enhanced sonography was performed in 55 patients with peripheral lung tumor. Among of them, malignant tumor was 40 cases, benign tumor was 15 cases. Analyzed the quantitative parameters （peak intensity, enhanced strength index） by using time-intensity curve （TIC） with computer. MVD was measured by immunohistochemistry after operation. Results The level of MVD in malignant tumor was significantly higher than that in benign tumor [ （24.57 ± 5.93）/HP vs. （15.50 ± 2.82）/HP] （P 〈 0.05 ）.The level of MVD had significant correlation with peak intensity and enhanced strength index （P 〈 0.01 ）. Conclusions The peak intensity and enhanced strength index have significant correlation with MVD. They are valuable indexes in evaluating angiogenesis in peripheral lung tumor.
出处
《中国医师进修杂志》
2013年第8期1-3,共3页
Chinese Journal of Postgraduates of Medicine
关键词
超声检查
介入性
肺外周性肿瘤
微血管密度
Uhrasonography, interventional
Peripheral lung tumor
Microvessel density
