摘要
目的 :探讨乙型肝炎病毒的泛嗜性。方法 :随机采取 45例乙型肝炎患者行胃粘膜活检 ,采用免疫组织化学SP法检测其胃粘膜中的HbcAg ;采用ELISA法检测静脉血HBsAg、HBeAg、抗 HBc。结果 :乙型肝炎患者胃粘膜中有HBcAg存在 ,主要呈弥漫胞浆型分布 ,腺腔和胃小凹及间质中也可见HBcAg颗粒 ;血清中HBV单项或多项阳性者 ,胃粘膜HBcAg阳性率相近 (75 %～ 80 % ) ;各类型乙型肝炎患者胃粘膜HBcAg阳性率比较 :CAH >CPH >PHLC ,但彼此之间差异不显著 (P>0 .0 5 )。结论 :胃粘膜中有HBcAg存在 。
s:Objective:To observe if there was HBcAg in the gastric mucosa of patients with hepatitis B.Methods:45 cases of such patients were collected with random sampling methods. HBcAg was detected in their gastric mucosa with a astroscope using immunocytochemistry methods(SP); HBV was detected in the serum with ELISA methods.Results:There were HBVs in the gastric mucosae of patients with hepatitis B.They were mainly in the cytoplasm,but they were also in the gastric pit,peptic glandular ducts and gastric extracelluar matrix.The pationts with one or many positive marks of HBV in the serum also have the postive HBcAg in the gastric mucosa (75%～80%).The postive rates of HBcAg in the gastric mucosa of hepatitis B were higher in CAH than in CPH and those in PHLC were the lowest,but the differences were not statistically significant( P >0.05).Conclusion:There were HBVs and maybe HBVs can be replicatied in the gastric mucosa of patients with hepatitis B.
出处
《镇江医学院学报》
2000年第3期436-438,共3页
Journal of Zhenjiang Medical College
