摘要
目的 :研究药物缓释物质CMC Na和 β CD对丁哌卡因毒性的影响。方法 :(1) 30只小白鼠被随机分为 3组 ,每组 10只 ,按 0 .0 5ml g剂量 (中毒致死剂量 ) ,将 0 .2 5 %丁哌卡因溶液、0 .2 5 %丁哌卡因CMC Na溶液和 0 .2 5 %丁哌卡因 β CD溶液分别予以 3组小鼠腹腔注射 ,记录各组小鼠腹腔给药后的中毒死亡时间 ;(2 ) 15 0只小白鼠被随机分为 3组 ,每组5 0只 ,根据实验药物的 5个给药剂量 ,3组小鼠再分为 5小组 ,记录各组小鼠实验药物 5个剂量腹腔注射后的死亡情况 ,采用Bliss法计算三种实验药物的LD5 0 值。结果 :0 .2 5 %丁哌卡因溶液、0 .2 5 %丁哌卡因 CMC Na溶液和 0 .2 5丁哌卡因 β CD溶液的死亡时间分别为 (0 .90± 0 .5 3)min、(5 .0 3± 1.6 6 )min和 (5 .83± 1.2 6 )min ;其LD5 0 值分别为 0 .0 16 0ml g、0 .0 197ml g和0 .0 188ml g。结论 :缓释物质CMC Na和 β
Objective: To investigate the effect of sustained release materials carboxymethylcellulose sodium(CMC Na)and β cyclodextrin(β CD)on the toxicity of local anesthetic bupivicaine.Methods:(1)30 rats were randomly divided into three groups and rats of each group( n =10) were injected intraperitoneally with 0.05ml/g of the 0.25% bupivicaine solution, 0.05ml/g of 0.25% bupivicaine CMC Na solution and 0.05ml/g of 0.25% bupivicaine β CD solution respectively.All the rats were died after drug injection and the times of death were recorded.(2)150 rats were randomly divided into three groups and rats of each group were injected intraperitoneally with above mentioned three solutions respectively.The LD50 of each solution was calculated by Bliss way.Results:The times of death of 0.25% bupivicaine solution,0.25% bupivicaine CMC Na solution and 0.25 % bupivicaine β CD solution were (0.90±0.53)min,(5.03±1.66)min and (5.83± 1.26 )min,and the LD 50 were 0.0160ml/g,0.0197ml/g and 0.0188ml/g respectively.Conclusions:Sustained release materials of CMC Na and β CD can potently lower the toxicity of local anesthetic bupivicaine.
出处
《镇江医学院学报》
2000年第3期428-430,共3页
Journal of Zhenjiang Medical College
关键词
局麻药
丁哌卡因
毒性
药物缓释
羧甲基纤维素钠
Local anesthetic
Bupivicaine
Toxicity
Sustained release materials
Carboxymethylcellulose sodium
β-cyclodextrin
