摘要
目的探讨右美托咪定对单肺通气(OLV)过程中炎性反应及氧化应激反应的影响。方法择期行食管癌根治术患者40例,ASAⅠ或Ⅱ级,年龄45～64岁,体重指数<30kg/m2,随机均分为两组:右美托咪定组(D组)和对照组(C组)。D组于气管插管后10min开始静脉输注右美托咪定1μg/kg(右美托咪定浓度为4μg/ml,输注时间10min),随后以0.5μg·kg-1·h-1持续输注至关胸。C组静脉输注等容量生理盐水作对照。于OLV开始即刻(T0)、OLV后60min(T1)和术毕(T2)采集肘静脉血,检测丙二醛(MDA)浓度和超氧化物歧化酶(SOD)的水平,酶联免疫法检测TNF-α和IL-6的浓度。结果与T0时比较,T2时两组血清SOD活性降低,MDA、TNF-α和IL-6的浓度升高(P<0.05);与C组比较,D组血清SOD活性升高,MDA、TNF-α和IL-6的浓度降低(P<0.05)。结论右美托咪定可抑制单肺通气过程中炎性反应和氧化应激反应,对临床实践中进行肺保护具有积极作用。
Objective To observe the effect of dexmedetomidine on inflammatory response and oxidative stress during one-lung ventilation. Methods Forty patients,ASA I or Ⅱaged 45-64,with body mass index lower than 30 kg/m^2, were randomly divided into two groups （n=20）： dexmedetomidine group （group D） and control group （group C）. Dexmedetomidine 1 μg·kg were infused 10 min after tracheal intubation, followed by eontinous infusion of dexmedetomidine at rate of 0.5 μg·kg^-1·h-1. Normal saline with equal volume were administrated in group C. Venous blood samples were obtained at three time points： the beginning of OLV, 60 min after OLV and the end of operation. MDA, SOD, TNF-a and IL-6 were detected. Results Compared to To, the activity of SOD were decreased, the plasma concentration of MDA, TNF-α and IL-6 were increased in both groups at T2 （P〈0.05） ; Compared to group C, the activity of SOD were increased in group D, the plasma concentration of MDA, TNF-α and IL-6 were decreased at T2 （P〈0.05）. Conclusion Dexmedetomidine could inhibit inflammatory response and oxidative stress during one-lung ventilation in patients udergoing elective resection of esophageal carcinoma, it has positive effect on the lung proteetion in clinical nroeess.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2013年第3期229-231,共3页
Journal of Clinical Anesthesiology
基金
河南省科技厅项目(122300410068)
关键词
右美托咪定
再灌注损伤
单肺通气
肺损伤
Dexmedetomidine
Reperfusion injury
One-lung ventilation
Lung injury
