摘要
目的观察不同动物实验感染广州管圆线虫情况,为进一步研究云南省广州管圆线虫病提供实验依据。方法从褐云玛瑙螺中分离广州管圆线虫第Ⅲ期幼虫,人工感染SD大鼠、昆明小鼠、豚鼠和家兔,观察感染情况。结果小鼠未能感染广州管圆线虫;豚鼠、家兔在感染广州管圆线虫后未获得成虫,仅发现少量幼虫寄生;感染不同时间后可在大鼠脊髓、脑、心和肺等部位发现各期广州管圆线虫。结论动物实验证明小鼠、豚鼠和家兔不是广州管圆线虫的适宜终末宿主,大鼠可作为广州管圆线虫感染理想的实验动物。
Objective The prevalence of Angiostrongylus cantonensis infection in laboratory animals was determined to provide an experimental basis for further investigation oi： Angiostrongyliasis cantonensis in Yunnan. Methods Four types of laboratory animals - SD rats, Kunming mice, guinea pigs and rabbits - were artificially infected with the third stage larvae of A. cantonensis isolated from Achatina fulica and the prevalence of infection was observed. Results Mice were not infected with A. cantonensis. Adult A. cantonensis were not obtained from guinea pigs and rabbits infected with A. cantonensis, and a few larvae were found. Worms were found in the liver, heart, lungs, and cerebrum of rats af-ter different periods of infection with A. cantonensis. Conclusion Mice, guinea pigs, and rabbits are nol suitable as fi-hal hosts of A, cantonensis. SD rats are an ideal for a laboratory animal model of A. cantonensis infection.
出处
《中国病原生物学杂志》
CSCD
北大核心
2013年第2期148-150,163,共4页
Journal of Pathogen Biology
关键词
广州管圆线虫
动物实验
感染
Angiostrongylus cantonensis
animal experiment
infection
