摘要
采用超高效液相色谱串联四级杆/飞行时间质谱仪(UPLC-Q-TOF MS)识别和鉴定了喹赛多在鸡体内的代谢产物,并讨论了喹赛多在鸡体内可能的代谢途径。按800mg/kg体重的剂量给鸡单次灌服喹赛多,采集试验前后鸡的粪便,经简单前处理后,运用UPLC-Q-TOF MS进行分析,采集的数据经Metabolynxxs软件处理后,共鉴定出15种喹赛多的代谢产物。试验结果表明,喹赛多在鸡体内发生广泛的代谢。
In this study,we identified the metabolites of cyadox in vivo produced by chicken using ultra performance liquid chromatography/quadruple time of flight tandem mass spectrometry（UPLC-Q-TOF MS）.Besides,it had been viewed that proposed metabolic pathways of cyadox in vivo of chicken.Animals were administered a single of cyadox（800 mg/kg） by oral gavage.We used UPLC-Q-TOF MS to analyze chicken feces,collected before and after the experiment,which were simple pretreatment.A total of fifteen metabolites were identified after the collected data processed by the software of Metabolynxxs.This experimental results showed that cyadox occurred widely metabolism in vivo of chicken.
出处
《中国畜牧兽医》
CAS
北大核心
2013年第3期11-19,共9页
China Animal Husbandry & Veterinary Medicine
基金
"973"国家重点基础研究发展计划课题(2009CB118801)
