摘要
目的探讨多囊卵巢综合征(PCOS)患者代谢综合征(MetS)及其组分的发生特点,评估MetS组分对PCOS患者罹患MetS发生风险的预测能力。方法选择2008年9月至2012年4月在福建省妇幼保健院妇科门诊诊断为PCOS患者208例及随机招募的体检者205例。PCOS诊断标准参照鹿特丹标准,MetS诊断标准依据国际糖尿病联盟(IDF)颁布的定义。所有受试者均进行人体测量和生化指标测定,比较两组MetS及其组分的发生特点,筛选对PCOS患者罹患MetS发生风险的预测指标。结果 208例PCOS患者MetS发生率为21.15%,明显高于对照组3.41%。具有1项及以上MetS组成成分的PCOS患者高达69.23%;血脂异常是主要的代谢紊乱,其次是高血压、空腹血糖异常。腰围(WC)结合高密度脂蛋白胆固醇(HDL-C)或腰围(WC)结合三酰甘油(TG)具有对PCOS患者发生MetS风险较高的预测能力。结论对于WC≥80cm的PCOS患者,一旦具备HDL-C<1.29mmol/L或TG>1.7mmol/L就应对其进行预防MetS发生的早期干预。
Objective To compare the prevalence of metabolic syndrome （MetS） and its abnormal components in poly- cystic ovary syndrome （PCOS） women, and analyze the ability of MetS components to predict MetS risk in PCOS patients. Methods A total of 208 PCOS women participated in this study between September 2008 and April 2012. The control group was comprised of 205 women recruited randomly. The analysis was done with PCOS patients who were diagnosed u- sing Rotterdam 2003 criteria. The MetS diagnostic criteria of the International Diabetes Federation （IDF） was used. All of the subjects were examined for anthropometric and biochemical parameters. We compared the incidence of MetS and its components between the two groups, and analyzed the ability of MetS components to predict MetS risk in PCOS patients. Results The prevalence of MetS in PCOS patients was 21.15% significantly higher than controls. PCOS patients with one or more MetS components were up to 69. 23%. Dyslipidemia was the most important feature of metabolic disorders, subsequently hypertension and impaired fasting glucose. WC coupled with HDL-C or WC coupled with TG gave relatively good predictions of the risk of MetS in Chinese patients with PCOS. Conclusion The early intervention to prevent the oc- currence of MetS was required for PCOS patients with WC ~〉 80 cm once dyslipidemia （ HDL-C 〈 1.29 mmol/L or TG 〉 1.7mmol/L） occurred.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2013年第3期192-196,共5页
Chinese Journal of Practical Gynecology and Obstetrics
基金
卫生部科学研究基金资助项目(WKJ2008-2-58)
福建省临床重点专科建设项目资助(闽财指20121589号)
关键词
多囊卵巢综合征
代谢综合征
血脂异常
polycystic ovarian syndrome
metabolic syndrome
dyslipidemia
