摘要
目的比较难治性抑郁症(TRD)患者治疗前后的认知功能变化。方法入组难治性抑郁症患者60例为研究组,60例健康者为正常对照组。使用威斯康星卡片分类(WCST)、韦氏记忆量表(WMS)、字色干扰实验(Stroop Test)、连线实验(Trails)、语言流畅性测试(VF)、画钟实验(Clock Copying)等神经心理测验工具评测患者的认知功能,并进行治疗前后上述指标的比较。结果①基线时,研究组WCST、WMS记忆商数、时空定向、数字顺数、累加、短时记忆、瞬时记忆、Stroop test、Trails、VF、ClockCopying等神经心理测验评分均与正常对照组存在显著性差异(t=-20.06～9.528,P<0.05);②研究组治疗后与基线相比,总应答数、持续错误数、随机错误数、完成分类数、记忆商数、个人经历、时空定向、数字顺数、累加、视觉再认、视觉再生、触觉、理解、倒背数字、Stroop test、Trails、VF、Clock Copying等评分均明显改善(t=-16.20～9.209,P<0.05);③研究组治疗后在总应答数、正确应答数、完成分类数、记忆商数、图片回忆、视觉再认、理解、C-W、VF、Clock Copying等评分与对照组存在显著性差异(t=-3.685～4.835,P<0.05)。结论 TRD患者的认知功能基线时表现脑功能的全面损害,治疗后显著改善,但在注意、短时记忆、工作记忆、干扰抑制、概念形成、认知灵活性等方面的认知功能损害不能完全恢复正常。
Objective To compare changes of cognitive function of patients with treatment-resistant depression before and after treatment. Methods A total of 60 TRD patients were assigned to research group and 60 healthy individuals to control group. Cog- nitive function of patients was assessed with a battery of neuropsychologieal evaluation instruments including WCST ,WMS, Stroop Test,Trails, VF and Clock Copying,then all indices above were compared before and after treatment. Results ①At baseline, There were significant differences between research group and control group in neuropsychological test scores of WCST,WMS memory quotient, space orientation, number order, accumulation, short-term memory, instantaneous memory, Stroop test, trails, VF ,and clock copying （t =-20. 06 - 9. 528, P 〈 0. 05 ）; ②After treatment, the scores on such factors as response administered, preservative errors, random errors, number of categories completed, memory quotient, personal experience, space orientation, number order, accumulation, vision recognition, design reproduction, touch memory, comprehension, digit span, Stroop test, trails, VF, as well as clock copying increased significantly compared with those at baseline（t=-16.20-9. 209 ,P〈0.05）;③After treatment ,the scores of number of total response ,number of correct response ,number of categories completed ,memory quotient ,picture recall ,vi- sion recognition,comprehension,C--W,VF,and clock copying in research group were significantly different from those in control group（t=-3. 685 - 4. 835, P〈 0. 05）. Conclusion The TRD patients＇ cognitive function which indicates the overall damage to brain function at baseline is improved after treatment. However,the impairment of cognitive function which appears in attention, short-term memory,working memory ,disturbance control,concept formation and cognitive flexibility is not recovered completely.
出处
《中国健康心理学杂志》
2013年第4期484-486,共3页
China Journal of Health Psychology
基金
淮安市科技支撑计划(工业
社会发展)项目(HAS08019)
关键词
精神病学
难治性抑郁症
认知功能
神经心理测验
Psychiatry
Treatment-resistant depression
Cognitive function
Neuropsychological evaluation
