摘要
目的:探讨远志皂苷、石菖蒲挥发油配伍对阿尔茨海默病模型大鼠学习记忆功能的影响,并探讨其作用机制。方法:将SD大鼠随机分为4组,即假手术组、模型组、远志皂苷和石菖蒲挥发油配伍组,脑复康组(即阳性药对照组),每组10只。采用D-半乳糖诱导建立阿尔茨海默病(AD)动物模型,观察远志、石菖蒲有效部位配伍对AD模型大鼠学习记忆能力、脑组织中SOD、AchE活性和MDA含量的影响。结果:与假手术组比较,模型组大鼠学习记忆能力明显减退,脑组织中SOD活性明显降低,AchE活性和MDA含量显著升高,远志石菖蒲有效部位配伍组学习记忆能力得到明显改善,脑组织中SOD活性得到明显提高,AchE活性和MDA含量均得到明显降低。结论:远志、石菖蒲有效部位配伍能明显改善阿尔茨海默病的学习记忆能力下降状况,其机制可能是通过抗自由基,恢复胆碱能系统,抑制其对脑组织的损伤。
Objective：To study the effect of the active parts compatibility of Radix Polygalae and Rhizoma Acori Talarinowii on mice with Alzheimer＇s disease（AD） and its possible mechanism.Methods：The SD rats were randomized into normal group,sham operation control group,model group,trearment group（the compatibility of senegenin and volatile oil of Rhizoma Acori Tatarinowii） and Naofukang group（positive drug control group）,10 animals in each group.AD animal model was induced by D-galactose.The ability of learning and memory,SOD and AchE activity and MDA contents in brain tissue were observed in AD rats treated with the compatibility of senegenin and volatile oil of Rhizoma Acori Tatarinowii.Results：Compared with sham operation control group,the ability of learning and memory decreased apparently,SOD activity decreased significantly and the activity of AchE and the content of MDA in brain tissue increased apparently in model group.Compared with model group,the ability of learning and memory improved apparently,SOD activity increased significantly and the activity of AchE and the content of MDA decreased apparently in trearment group.Conclusion：The active parts compatibility of Radix Polygalae and Rhizoma Acori Talarinowii improve the learning and memory ability of AD mice significantly,and its mechanism is probably relevant with anti-free radicals and the inhibition on brain tissue injury.
出处
《中华中医药学刊》
CAS
2013年第3期473-475,共3页
Chinese Archives of Traditional Chinese Medicine
基金
教育部高校博士点专项基金资助项目(20103322120003)
浙江省中医药管理局资助项目(2011ZA020)
