摘要
目的探讨广东地区汉族人群Fam96B基因单核苷酸多态位点rs3890213_A>G与冠心病的关系。方法利用聚合酶链式反应-连接酶检测反应分析技术,对274例健康对照个体(对照组)和294例冠心病患者(病例组)的Fam96B基因rs3890213_A>G多态位点进行分型,采用非条件逻辑回归分析统计该多态位点与冠心病易感的相关性。结果 AA、AG、GG基因型在病例组中的频率分别为2.0%、33.0%和65.0%,在对照组中分别是4.4%、24.5%和71.2%。非条件逻辑回归分析发现,以AA基因型作为参照,AG和GG基因型均没有显著增加个体患冠心病的风险(OR=2.74,95%CI为0.82～9.11,P=0.101;OR=1.80,95%CI为0.56～5.81,P=0.324)。结论 Fam96B基因rs3890213_A>G多态位点与广东汉族人群冠心病易感无相关性。
Objective To investigate the correlation between the Fam96B rs3890213 polymorphism and the risk for coronary artery disease in ethnic Han Cantonese population. Methods The genotypes of the Fam96B rs3890213_A 〉 G polymorphism were determined in 294 coronary artery disease （ CAD ） patients and 274 healthy donors by polymerase chain reaction -ligase detection reaction. The correlation between the polymorphism and the risk for coronary artery disease was evaluated using unconditional logistic regression analysis. Results The frequencies of AA, AG and GG genotype were 2. 0, 33.0 and 65.0% , respectively, in CAD subjects; and 4. 4, 24. 5 and 71.2% , respectively, in controls. No significantly increased risk for CAD was observed for those carrying G allele （ OR = 2.74, 95% CI = 0. 82 - 9. 11, P = 0. 101 and OR = 1.80, 95% CI =0. 56 -5.81, P =0. 324）. Conclusion Fam96B rs3890213 polymorphism is not associated with coronary artery disease in ethnic Han Cantonese population.
出处
《广东医学》
CAS
CSCD
北大核心
2013年第3期368-370,共3页
Guangdong Medical Journal
基金
国家自然科学基金(编号:81000143)
广东医学院建博科技创新团队项目(编号:STIF201102)
关键词
Fam96B
冠心病
单核苷酸多态性
遗传易感性
Fam96B
coronary artery disease
single nucleotide polymorphism
genetic susceptibility
