摘要
肾小管上皮细胞间充质转分化(epithelial to mesenchymal transition,EMT)是肾间质纤维化(renal interstitial fibro-sis,RIF)的重要发病机制,其关键步骤包括"肾小管上皮细胞黏附性消失、间充质细胞标志性蛋白表达和细胞骨架蛋白重组、肾小管基底膜破坏、细胞迁移能力增强"等。这些关键步骤不仅与多条细胞信号通路的调控作用有关,而且,在体内外可被一些单味中药(黄芪、冬虫夏草、丹参等)及其提取物以及中药复方(黄芪当归合剂、益气活血方等)所干预。中药通过干预肾小管EMT病变过程而改善肾间质纤维化。
Epithelial to mesenchymal transition（EMT） has been proposed as a key role leading to the progressive tubulo-inter- stitial fibrosis（TIF）. The tubular EMT is an highly regulated process involving four key steps including：loss of epithelial eell adhesion, de novo smooth muscle actin expression and actin reorganization, disruption of tubular basement membrane, and enhanced cell migration and invasion. These crucial processes are closely connected to the relative actions on many signaling pathways in EMT. Additionally, increasing evidences suggest that some Chinese herbal medicines and their extracts, such as Astragali Radix, Cordyceps, Salvia miltior- rhiza, as well as Chinese herbal prescriptions including Astragalus Angelica mixture and Supplementing Qi and activating blood circula- tion decoction,could intervene the related events controlling EMT both in vitro and in vivo. Chinese herbal medicines could ameliorate TIF by intervening the course of EMT.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2013年第5期648-652,共5页
China Journal of Chinese Materia Medica
基金
江苏高校优势学科建设工程项目
关键词
慢性肾脏病
肾间质纤维化
肾小管上皮细胞间充质转分化
中药
chronic kidney disease
tubulo-interstitial fibrosis
epithelial to mesenchymal transition
Chinese herbal medicine
