摘要
MicroRNA(MiRNA,miR)通过调节信使RNA(mRNA)的表达,广泛参与心血管系统细胞的增殖、迁移、分化、凋亡等病理生理过程,在心血管系统疾病的发生发展过程中起着重要的调控作用。越来越多的研究表明,针对缺血性心血管疾病的发病机制,通过特异性调节miRNA的活性,抑制相关蛋白的表达,对各种缺血性心脏病具有显著的治疗作用。但目前开发miRNA靶向治疗药物尚缺乏大规模的临床试验研究,其有效性和安全性需进一步证实。本文旨在综述MicroRNA在靶向治疗缺血性心脏病中的研究进展,以期为开发MiRNA靶向治疗药物治疗缺血性心脏病提供更多的理论依据。
MiRNA mediated various pathophysiological processes of cells in cardiovascular system, such as the proliferation, migration, differentiation, apoptosis, and so on, and played an important role in the development of cardiovascular diseases by regulating the expression of mRNA. More and more researches suggested that according to the pathogenesis of ischemic cardiovascular diseases, miRNA had remarkable curative effects on various ischemic cardiovascular diseases through specifically regulating the activities of miRNA and inhibiting the expressions of associated protein. But development of miRNA targeted therapeutic drugs were still lack of large-scale clinical trials, the efficacy and safety need to be further identified. This article was aimed to review the research progress of miRNA as therapeutic targets in ischemic heart disease and provide more theories for the development of miRNA targeted therapeutic drugs for ischemic cardiovascular diseases.
出处
《现代生物医学进展》
CAS
2013年第3期570-572,518,共4页
Progress in Modern Biomedicine
