摘要
硫氰酸红霉素的生产是通过在酸性条件下反应结晶的方式制备,其稳定性直接影响产品的纯度。本文用磷酸缓冲盐溶液调节反应体系的pH,研究了硫氰酸红霉素各组分的降解率随pH的变化。结果表明,在硫氰酸红霉素的A、B、C 3种组分中,以活性组分A的稳定性受pH值的影响最大;pH在4.5时,硫氰酸红霉素A能够在40min内保持稳定,超过40min会发生降解;而当pH小于4.0时,硫氰酸红霉素A组分发生快速降解。文章探讨了红霉素A的降解机理,并研究了等摩尔硫氰酸根条件下红霉素A组分降解动力学,得到的模型与实验结果吻合良好,与文献对比,说明等摩尔硫氰酸根的存在降低了红霉素A的降解速率。
Erythromycin thiocyanate is producted in acid solution by reactive crystallization method, whose purity is effeeted by its acid stability. In this paper, pH was regulated by phosphate buffer and the stabilities of components of erythromycin thiocyanate under different pH were researched. The results show that during the three components of erythromycin thiocyanate, A, B and C, pH has the largest effect on the stability of A. When the pH is 4.5, erythromy- cin thiocyanate A can be steady in 40min and then will degradate; when pH is under 4.0, erythromycin thiocyanate A will degradate fastly. The degradation mechanism is stated, at the same time, the degradation kinetics of erythromycin A when [SCN]- exist in acid solution was also described by equation rA=1.93×10^4CAC[H]＋^1.59, which is found to be in line . with the experimental results. Compared with the result that w^thout [SCN]-, a conclumon that degradation rate of erythromycin A is droped by [SCN]-.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2013年第3期218-222,共5页
Chinese Journal of Antibiotics
关键词
硫氰酸红霉素
降解
动力学
Erythromycin thiocyanate
Degradation
Kinetic
