摘要
目的 观察尼尔雌醇替代治疗对绝经后妇女血脂及血液流变学的影响。 方法 对 36例绝经后妇女用尼尔雌醇进行替代治疗 ,剂量为每半月 2mg ,共 6月 ,最后 7d加用安宫黄体酮 8mg·d-1,于用药前和治疗 6月后分别测血脂及血液流变学指标。 结果 尼尔雌醇替代治疗 6月后血总胆固醇 (TC)、低密度脂蛋白胆固醇(LDL C)、TC/高密度脂蛋白胆固醇 (HDL C)、LDL C/HDL C均明显下降 (P <0 0 1) ,HDL C明显升高 (P <0 0 1) ,血纤维蛋白原 (PFC)、全血粘度 (ηb)、血浆粘度 (ηp)、细胞压积 (HCT)均显著下降 (P <0 0 1) ,血液还原粘度 (ηr)明显下降(P <0 0 5 )。 结论 用尼尔雌醇替代治疗能明显改善血脂紊乱 ,降低血粘度。
Objective To investigate the effect of nylestriol(CEE3) replacement therapy on lipid and hemorrheology in 36 postmenopausal women. Methods CEE3 was given to the postmenopausal women with a dose of 2mg per 15 days for six months.Medroxyprogesterone acetate was given with a dose of 8mg per day for last seven days.Iipid levels and hemorrheology were measured before and after 6 months therapy. Results The level of lipids(TG,LDL-C,TC/HDL-C,LDL-C/HDL-C)wese decreased significantly( P <0 01),and the level of HDL-C was elevated significantly( P <0 01)after 6 months therapy.The parameters of hemorrheology(PFC,ηb,ηp,HCT)were decreased significantly( P <0 01),the level of ηr was lowered after replacement therapy( P <0 05). Conclusions CEE3 replacement therapy improves lipid disorders and hemorrheology.
出处
《实用老年医学》
CAS
2000年第4期201-202,共2页
Practical Geriatrics
关键词
绝经后妇女
尼尔雌醇
替代治疗
血脂
冠心病
Postmenopausal women Nylestriol(CEE3) Replacement therapy Lipid Hemorrheology
