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重组抗体高效表达的研究进展(Ⅱ) 被引量：1

Progress in research on high expression of recombinant antibody(Ⅰ)
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摘要 （续上期）2抗体基因序列的优化 越来越多的研究表明,抗体基因序列中存在的剪接信号、二级结构、GC含量以及密码子偏爱等影响抗体的表达水平。信号肽会影响抗体折叠、 The high expression of recombinant antibody in mammalian cells is dependent on the construction of high expression vector,optimization of antibody gene sequence,screening of stable antibody-expressing cell strains,modification of host cells as well as optimization of cell culture process.The progress in research on above-mentioned problems is reviewed in this paper.
作者 胡迪超 张爱华 杨晓明
机构地区 武汉生物制品研究所有限责任公司 中国生物技术股份有限公司
出处 《中国生物制品学杂志》 CAS CSCD 2013年第2期280-288,共9页 Chinese Journal of Biologicals
关键词 重组抗体 高效表达 基因序列 二级结构 GC含量 信号肽 密码子 Recombinant antibody Expression
分类号 R392.11 [医药卫生—免疫学]
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参考文献67

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共引文献10

同被引文献18

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中国生物制品学杂志
2013年 第2期

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