期刊文献+

妊娠合并甲状腺功能减退症26例妊娠结局分析 被引量:20

Outcome of 26 Pregnant Women with Hypothroidism
原文传递
导出
摘要 目的:对妊娠合并甲状腺功能减退症进行分析,探讨其对母儿的影响,及孕期筛查甲状腺功能有无意义。方法:对我院26例妊娠合并甲减的临床资料进行回顾性统计分析。结果:26例妊娠合并甲减病例中有1例早产(孕33周),其余25例患者维持至足月妊娠,其中剖宫产17例(65.38%),合并妊娠期高血压疾病5例(19.23%),妊娠期糖尿病3例(11.53%),羊水胎粪污染3例(11.54%),新生儿无先天性甲减。经过治疗后甲状腺功能减退孕妇的剖宫产率,糖尿病发生率、高血压疾病发生率、羊水粪染的发生率较对照组增加;但两组妊娠结局差异无统计学意义(P>0.05)。结论:妊娠合并甲状腺功能减退症孕妇多种妊娠并发症的发病率高于正常孕妇,应加强对妊娠甲减的早期筛查及治疗,可有效降低不良妊娠结局,减少先天性甲低的出生。 Objective: To analyze the maternal and fetal outcome of pregnant women combined with treated hypothroidism, and analyze the value of early screening of thyroid ruction. Methods: Data of 26 cases of pregnant women with hypothyroidism were analyzed retrospectively. Results: In 26 cases of pregnant women with hypothyroidism, 1 was preterm labor, 25 full-term pregnancy, 17 uterine lower segment cesarean section (65.38%), 5 hypertensive disorders complicating pregnancy (19.23%), 3 gestational diabetes mellitus (11.53%), 3 meconium-stained amniotic fluid (11.54%), no congenital hypothyroidism. The patients in hypothyroidism group had a higher risk of cesarean-section, gestational diabetes mellitus, gestational hypertension and meconium-contaminated amniotic fluid but there was no statistical difference between hypothyroidism and control group (P〉0.05). Conclusion: The incidence of the pregnancy complication with hypothy- roidism increased than normal pregnancy women. Early sceening and proper treatment for the pregnant women with hypothyroidism can effectively reduce the adverse pregnancy outcome, and the birth of congenital hypothyroidism.
出处 《现代生物医学进展》 CAS 2013年第2期309-311,共3页 Progress in Modern Biomedicine
关键词 甲状腺功能减退症 妊娠并发症 妊娠结局 Hypothyroidism Pregnancy complicationgs Pregnancy outcome
  • 相关文献

参考文献20

  • 1TENG WP. Recent progress in hyopothyroidlsm during pregnancy[J]. Chin J Enduocrinol Metab, 2008,24:595-596.
  • 2Poppe K,Glinoer D.Thyroid autoimmunity and hypothyroidism before and during pregnancy[J].Hum Reprod Update,2003,9(2): 149-161.
  • 3时娟娟,蔺莉.妊娠合并甲状腺功能异常的相关问题研究[J].中国全科医学,2011,14(2):113-115. 被引量:45
  • 4MontoroMN.Management of hypothyroidism during pregnancy[J].Clin ObstetGynecol, 1997, 40(1): 65-80.
  • 5王薇薇,单忠艳.妊娠期甲状腺疾病筛查策略[J].中国实用内科杂志,2010,30(4):386-388. 被引量:30
  • 6Benhadi N, Wiersinga WM, Reitsma JB, et al. Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death[J]. Eur J Endocrinol, 2009,23,31 (6):523-535.
  • 7Idris I, Srinivasan R, Simm A, et al. Maternal hypothyroidism in early and late gestation: effects on neonatal and obstetric outcome [J]. Clin Endocrinol, 2005,63(5):560-565.
  • 8Robert P J, Ronald PS, Bakker K, et al. Thyroid dysfunction during pregnancy and in the first postpartum year in women with diabetes mellitustype 1 [J]. Eur J Endocrinol, 2002,47:443-451.
  • 9Uchiyama S, Imamura N, Hidaka H, et al. An unusual variant of a left paraduodenal hernia diagnosed and treated by laparoscopic surgery: reoort of a case[J]. Surg Today, 2009,39(6):533-535.
  • 10Rovelli R, Vigone MC, Giovanettoni C, et al. Newborn of mothers affected by autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life[J]. Ital J Pediatr, 2010,36:24.

二级参考文献51

  • 1龙燕,徐蕴华.妊娠合并甲状腺功能亢进[J].实用妇产科杂志,2006,22(10):578-580. 被引量:10
  • 2Haddow JE, Palomaki GE, Allan WC, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child[ J ]. N Engl J Med, 1999,341:549 - 555.
  • 3Pop VJ, Brouwers EP, Vader HL, et al. Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study [ J]. Clin Endocrinol (Oxf), 2003,59: 282 - 288.
  • 4Abalovich M,Amino N, Barbour LA, et al. Management of thyroid dysfunction during pregnancy and postpartum : an endocrine society clinical practice guideline[ J ]. J Clin Endocrinol Metab,2007,92: S1 - S47.
  • 5Vaidya B, Anthony S, Bilous M, et al. Detection of thyroid dysfunction in early pregnancy:universal screening or targeted high-risk case finding[ J]. J Clin Endocrinol Metab,2007,92:203 - 207.
  • 6Berbol P, Mestre JL, Santamarfa A, et al. Delayed aeurobehavioral development in children born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation [J].Thyroid, 2009,19 ( 5 ) : 511 - 519.
  • 7Negro R, Formoso G, Mangieri T, et al. Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease:effects on obstetrical complications [ J ]. J Clin Endocrinol Metab, 2006, 91:2587 - 2591.
  • 8Negro R, Greco G, Mangieri T, et al. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies [J]. J Clin Endoerin Metab, 2007,92(4) :1263 - 1268.
  • 9Dosiou C, Sanders GD, Araki SS, et al. Screening pregnant women for autoimmune thyroid disease : a cost-effectiveness analysis [ J ]. Eur J Endocrinol,2008,158(6) :841 -851.
  • 10Thung SF,Funai EF, Grobman WA. The cost-effectiveness of universal screening in pregnancy for Subclinical hypothyroidism [ J ]. Am J Obstet Gynecol,2009,267(3) :e1 -7.

共引文献145

同被引文献137

  • 1何丽萍.孕妇甲状腺功能异常对妊娠结局的影响[J].中国综合临床,2005,21(3):273-275. 被引量:27
  • 2卢天华,孟志英.妊娠合并甲状腺功能减退38例分析[J].新乡医学院学报,2007,24(3):283-285. 被引量:8
  • 3祁建青,杜鸿,沈洁,尤莉芳.妊娠合并甲状腺功能减低对妊娠结局和胎儿影响的研究[J].中国妇幼保健,2007,22(17):2327-2329. 被引量:26
  • 4陆再英,钟南山.内科学[M].第7版.北京:人民卫生出版社.2008:251.
  • 5Negro R, Schwartz A, Gismondi R, et al. Universal screening versus case finding for detection and treatment of thyroid hor- monal dysfunction during pregnancy [J] . J Clin EndocrinolMetab, 2010, 95 (4) : 1699 - 1705.
  • 6Stagnaro - Green A, Abalovich M, Alexander E, et al. Guid- elines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and post- partum [J] . Thyroid, 2011, 21 (10): 1081-1126.
  • 7Leung AM. Thyroid function in pregnancy [J] . J Trace Elem MedBiol, 2012, 26 (3): 138-1gl.
  • 8Uchiyama S,Imamura N,Hidaka H. An unusual variant of a left paraduodenal hernia diagnosed and treated by laparoscopic surgery:report of a case[J].{H}SURGERY TODAY-THE JAPANESE Journal OF SURGERY,2009,(06):533-535.
  • 9黄瑞萍,吴贤,周红.孕妇甲状腺功能减退与妊娠结局的相关性分析[J].现代预防医学,2008,35(1):61-62. 被引量:27
  • 10Negro R, Sehwarwartz A, Gismondi R, et al. Increased pregnancy loss rate in thyroid antibody negative women with TSH leves between 2.5 and 5.0 in the first trimester of pregnancy [ J ]. J clin Endocrinol Metab,2010,95 (9):E44-E48.

引证文献20

二级引证文献137

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部