摘要
作者动态观察了 CCl_4诱发大鼠肝硬变中卵圆细胞(OC)的变化。用药后4周肝汇管区 OC 始增生,8～12周汇管区及肝小叶内出现大量团状或条索状排列的 OC,其周围常伴 desmin 阳性细胞存在。OC 聚集处,体积缩小,嗜碱性增强,趋向围成管腔;肝细胞大片坏死区,OC 分散,体变大,胞浆丰富,颇与再生肝细胞相近。18周后肝硬变形成时,管状排列的 OC 演变为新生胆管。结果显示OC 可能向肝细胞和胆管上皮细胞双向分化,作为一种“干细胞”参与肝硬变发生。
Liver cirrhosis was induced by injecting 50% CCl_4 subcutaneously into the rates. The sequential changes of oval cells were observed.It was found that oval cells proliferated first in portal areas 4 weeks after injection of CCl_4.From 8 to 12 weeks the oval cells,which were fre- quently surrounded by desmin-positive cells,increased in number in portal areas arid hepatic lob- ules.The oval cells in their concentrative areas decreased in volume,increased basophilic stain and formed tubular structures;while in large necrotic areas of hepatocytes,the oval cells inereased in volume and in cytoplasm.New bile ductules were formed by tubular structures of oval cells in late period.The results suggested that oval cells might differentiate to hepatocytes and bile ductular cells and they were related to the cirrhotic process as a“stem cells”.
出处
《滨州医学院学报》
1991年第4期26-28,95,共3页
Journal of Binzhou Medical University
关键词
卵圆细胞
肝硬变
肝细胞
双向分化
oval cell
cirrhosis
bile ductular cell
hepatocyte
double differentiation
