摘要
作者对52例冠心病、35例原发性高血压病和20例正常人,进行外周血淋巴细胞培养,采用姐妹染色单体互换(SCE)技术,检测其DNA修复功能。冠心病组SCE均值为9.01±0.31,高血压病组SCE均值为8.44±0.33,二者与正常人对照组SCE均值4.06±0.12相比较,差异极显著(P<0.01)。同时观察高血压病Ⅲ期及急进型高血压SCE均值高于Ⅱ期(P<0.01),差异显著。表明冠心病、高血压病可能与DNA损伤修复功能障碍有关,对进一步探讨其发病机理有重有意义。
We adopted the technics of SCE to examine the repair function of DNA in the peripheral lymphocytes of 52 patients with coronary heart disease and 35 with essential hypertension disease and compared them with 20 normal adults. The results were as follows: the coronary heart disease group had a mean frequency of SCE per metaphase of 9.01±0.31 and the essential hypertension disease group of 9.44±0.33. Whereas the adult control group had a mean frequency of SCE per metaphase of 4.06±0.12. The mean frequency of two deseases was significantly higher than that of the normal adults(P<0.01). The SCE frequency in the essential hypertension Ⅲ and acute essential hypertension were significantly higher than the essential hypertension Ⅱ (P<0.01). AS far as our information goes, we ascribe the coronary heart disease and the essential hypertension disease to post-recombination repair deficiency of DNA. The above results indicate that it is of great importance to study the machanism of coronary heart disease and essential hypertension disease.
出处
《滨州医学院学报》
1991年第1期4-6,93,共3页
Journal of Binzhou Medical University
关键词
冠心病
高血压病
SCE频率
coronary heart disease
essential hypertension disease
frequency of SCE
