摘要
目的:探讨宁波市耐药结核病的流行现状及相关影响因素。方法:将宁波地区2010年-2011年进行耐药监测的新发及复治痰培养阳性肺结核病例所分离菌株进行菌型鉴定及抗菌药物敏感性测定和分析。结果:研究痰培养阳性肺结核患者1321例,其中结核分枝杆菌复合群1123例(占85.0%),非结核分枝杆菌198例(占15.0%),结核分枝杆菌中总耐药率为29.0%,耐多药率为7.9%。新发患者耐药率为25.6%,耐多药率为4.6%,复治患者耐药率为50.3%,耐多药率为28.4%,复治患者耐药率高于新发患者(χ2=39.573,P<0.05)。经多因素非条件logistic回归分析,化疗史是影响耐药的主要因素。结论:宁波地区耐药结核病疫情较严峻,须进一步加强结核病防治措施。
Objective： To find out the status and risk factors of drug - resistant tuberculosis in Ningbo district. Methods： All sputum culture positive patients confirmed at any district tuberculosis dispensary in Ningbo from 2010 to 2011 were enrolled. The drug susceptibility tests of isoniazid, rifampiein, streptomycin and ethambutol was per- formed by the proportion method. Univariate and multivariate analysis were performed to determine the risk factors associated with drug resistance. Results ： One thousand, one hundred and twenty - three myeobacterium tuberculosis were enrolled during the study period. The total frequency of drug resistance was 29.0% （326/1123 ） , the total fre- quency of multi- drug resistance was 7.9% （89/1123）. Initial drug resistance was 25.6% （248/968）, initial multi - drug resistance was 4.6% （45/968）, acquired drug resistance was 50.3% （78/155） and acquired multi - drug resistance was 28.4% （44/155）. A history of previous treatment for tuberculosis were significantly associated with drug resistance. Conclusion： The prevalence of drug - resistant tuberculosis was relatively high in Ningbo, suggesting the necessity to strengthen the tuberculosis control program for patients.
出处
《中国卫生检验杂志》
北大核心
2013年第2期495-497,共3页
Chinese Journal of Health Laboratory Technology
关键词
结核
耐药
Tuberculosis
Drug - resistance
