摘要
目的:了解重症监护病房(ICU)病原菌的分布及耐药情况,指导临床有效预防及合理用药。方法:从2009年-2011年中国中医科学院望京医院ICU分离的所有病原菌,采用K-B纸片扩散法进行药敏试验,并使用WHONET5.5对药敏数据进行分析。结果:分离的438株病原菌中,革兰阴性菌316株,革兰阳性菌87株,真菌35株;革兰阴性非发酵菌比例较高,占了革兰阴性菌的59.2%;肺炎克雷伯菌77株,大肠埃希菌18株,占革兰阴性菌的30.1%,其中产超广谱β内酰胺酶(ESBLs)的比例高达69.5%;革兰阳性菌以金黄色葡萄球菌为主,其中耐甲氧西林金黄色葡萄球菌(MRSA),占到了92.8%。结论:ICU患者病情重,感染多,耐药情况严重,应加强耐药监测,严格按照临床用药方案合理使用抗菌药物。
Objective ：To investigate the distribution and drug resistance of pathogens,and guide effective preven- tion and rational drug use in clinic. Methods： All the pathogens isolated in ICU from 2009 to 2011 in Wangjing were carried out drug sensitivity test by K - B method, and the test resuhs were analyzed by WHONETS. 5. Re- sults： Of 438 clinical isolates, gram negative organisms accounted for 316 strains, gram positive organisms accoun- ted for 87 strains and fungus accounted for 35 strains. The non - fermenters were predominant in Gram - negative bacteria （59.2%）, followed by Klebsiella （77 strains） ,E -coli（ 18 strains） （30.1%）, in which ESBLs accounted for 69.5%. Staphylococcus aureus were predominant ill Gram -positive bacteria（69 strains） , in which the percent- age of methicillin - resistant Staphylococcus aureus （MRSA） was about 92.8%. Conclusion： ICU patients were sus- ceptible to multiple infections and severe drug resistance, so it is necessary to enhance drug resistance monitoring and use antimicrobial agents in accordance with clinical therapeutic program on these patients .
出处
《中国卫生检验杂志》
北大核心
2013年第2期492-494,497,共4页
Chinese Journal of Health Laboratory Technology
