摘要
目的:探讨妊娠期肝内胆汁淤积症(ICP)血小板变化的临床意义,为临床观察提供参考依据。方法:109例ICP为观察组,121例健康孕妇为对照组,测定血小板参数、血生化参数,比较分析。结果:观察组血小板计数下降、血小板平均体积、血小板分布宽度、大血小板比例,较对照组明显增加,差异有统计学意义(P<0.05或P<0.01)。观察组血小板平均体积与血浆甘胆酸水平之间呈低度正相关(r为0.21,P<0.05)。结论:ICP患者血小板参数测定,可以作为ICP病情观察的辅助参考指标,有助于减少产后出血的医学干预,保护母婴健康。
Objective：To study the clinical significance of platelet changes in patients with intrahepatic cholesta- sis of pregnancy and to provide a reference for observation of intrahepatic eholestasis of pregnancy. Methods： One hundred and nine cases of hospitalized patients with intrahepatic cholestasis of pregnancy as objective group and one hundred and twenty - one cases of hospitalized healthy pregnant women as control group were selected to determine the platelet parameters, blood biochemical parameters. Then the comparative study was done. Results： There is a lower degree of platelet counts and a higher degree of mean platelet volume, platelet distribution width, platelet - large cell ratio in patients with intrahepatic cholestasis of pregnancy in observation group than those in control group （ P 〈 0.05 or P 〈 0.01 ）. There was a low positive correlation （ r = O. 2 !, P 〈 0.05 ） between MPV and plasma glyco- cholic acid in patients with intrahepatic cholestasis of pregnancy in observation group. Conclusion： The fact shows that measurement of platelet parameters in patients with intrahepatic cholestasis of pregnancy may be used as the auxiliary observation ICP reference index. It should be helpful to reduce medical intervention of postpartum hemor- rhage, and protect the maternal and child health.
出处
《中国卫生检验杂志》
北大核心
2013年第2期428-430,共3页
Chinese Journal of Health Laboratory Technology
关键词
妊娠期肝内胆汁淤积症
血小板平均体积
血小板分布宽度
产后出血
Intrahepatic cholestasis of pregnancy
Mean platelet volume
Platelet distribution width
Postpartumhemorrhage
