摘要
目的:观察非酒精性脂肪性肝炎合并腹型肥胖患者血清脂联素含量的变化,并探讨其临床意义。方法:通过检测非酒精性脂肪性肝炎合并腹型肥胖患者(合并组)、单纯非酒精性脂肪性肝炎患者(单纯组)和健康对照者血清脂联素含量,分析合并组患者血清脂联素含量变化,并通过其与胰岛素抵抗指数、血清肝功能、血脂的相关性分析,探讨其临床意义。结果:合并组患者血清脂联素含量明显低于单纯组和健康对照组(P<0.01)。血清脂联素含量与腰围、体重指数、空腹血糖、血清胰岛素、HOMA-IR呈显著负相关,与血清ALT、AST、GGT活性及血清TG、TC、LDL-C含量亦显著负相关,与血清HDL-C含量则呈显著正相关。结论:合并组患者存在严重的低脂联素血症,腹型肥胖可能通过加重低脂联素血症进一步加重非酒精性脂肪性肝炎。
Objective：To observe the changes of serum adiponectin in patients with non - alcoholic steatohepatitis and abdominal obesity, and to explore the clinic significance of serum adiponectin. Methods ： To analyze the chan- ges of serum adiponectin in patients with non - alcoholic steatohepatitis and abdominal obesity （ combined group ）, simple non - alcoholic steatohepatitis patients （ single group） and healthy controls group. Then the clinical signifi- cance of serum adiponectin was explored through correlation analysis of serum adiponectin among HOMA - 1R, ser- um liver function, blood lipids. Results： The adiponectin content in serum of combined group was lower than that of the simple group and healthy control group （P 〈 0.01 ）. The adiponectin content in serum was significantly negative- ly correlated with waist circumference, body mass index, fasting blood glucose, serum insulin, HOMA - IR, ALT, AST and GGT activity in serum, TG, TC, LDL - C content, while positively correlated with HDL - C content in ser- um. Conclusion： The severe hypoadiponectinemia exist in combined group patients. Abdominal obesity may further aggravate the non- alcoholic steatohepatitis by aggravating hypoadiponectinemia.
出处
《中国卫生检验杂志》
北大核心
2013年第2期338-341,共4页
Chinese Journal of Health Laboratory Technology
基金
浙江省中医药科技计划(2009YA019)
关键词
非酒精性脂肪性肝炎
腹型肥胖
血清脂联素
临床意义
Non- alcoholic steatohepatitis
Abdominal obesity
Serum adiponectin
Clinic significance
