摘要
目的:探讨高龄食管癌患者术前准备及新辅助化疗对外科手术治疗的作用。方法:142例60岁及以上高龄患者的术前准备方式进行回顾性总结和分析。观察组采用新辅助化疗+手术治疗,单纯手术组采用单纯手术治疗。所有病人术前均采用螺旋CT进行分期、评估。结果:观察组根治性手术切除率为93.8%(75/80),对照组为69.3%(43/62)。两组比较有统计学意义(P<0.05)。观察组术后并发症发生率为41.3%(33/80),单纯手术组为32.3%(20/62),围手术期均无死亡,两组术后并发症发生率比较,差异无统计学意义(P>0.05)。结论:与单纯手术相比,中晚期食管癌术前新辅助化疗结合手术治疗能显著提高老年患者根治性手术切除率。螺旋CT扫描对评估食管癌术前分期具有重要价值,是评估手术适应证的重要检查手段之一。
Objective： To explore the role of preoperative preparation and neo-adjuvant chemotherapy in surgical treatment for senile esophageal cancer. Method： Clinical data of the preoperative preparation from 142 patients of and above 60 years old were colleted and analyzed retrospectively. The patients were di- vided into observation group and control group. Patients in observation group received surgical treatment ac- companied by neo-adjuvant chemotherapy, while those in control group received surgical treatment alone. Spiral computed tomographs（ spiral CT） were conducted for all patients included before surgical treatment for cancer stage identification and assessment. Result： The rate of radical operation in observation group was 93.8% （75/80}, and 69.3% （43/62} in control group, with a statistical significance in the difference of radical operation rate between the two groups （ P〈0.05 }. The rate of post-operational complications was 41. 3% （33/80） in observation group, and 32.3% （20/62） in control group, without case mortality in both groups. There was no statistical significance in the difference of post-operational complications between the two groups（P〉0.05）. Conclusion： Compared with conducting surgical treatment alone, the accompanied neo-adjuvant chemotherapy in treating medium and advanced stage of senile esophageal cancer could signifi- cantly enhance the radical operation rate among senile patients. The spiral CT plays an important role in as- sessing the cancer stages preoperativelyw thus should be considered as an essential way in the admission for surgical indication of senile esophageal cancer.
出处
《河北医学》
CAS
2013年第4期500-503,共4页
Hebei Medicine
关键词
高龄
食管癌
新辅助化疗
外科治疗
螺旋CT
Senile
Esophageal cancer
Neo- adjuvant chemotherapy
Surgical treatment
Spiral computed tomographs
