摘要
目的探讨体检人群非酒精性脂肪性肝病(NAFLD)与代谢综合征(MS)相关指标的关系。方法选择2010年和2011年连续在我院体检中心参加年度体检的昆明铁路局职工共1 367例作为研究对象,根据两次体检的腹部B超结果判断有无NAFLD,将体检者分为阴性组890例(无→无)、新增组145例(无→有)、阳性组257例(有→有)、减少组75例(有→无)。记录NAFLD总检出率并分析NAFLD与MS相关指标的关系。结果 2010年NAFLD总检出率为24.3%(332/1 367),2011年为29.4%(402/1 367),差异有统计学意义(χ2=18.514,P<0.05)。除2011年各组总胆固醇(TC)水平差异无统计学意义外,各组2010年、2011年MS相关指标比较,差异均有统计学意义(P<0.05)。多因素分析结果显示,体质指数(BMI)升高〔OR=1.48,95%CI(1.06,1.74)〕对NAFLD新增模型的影响有统计学意义(P<0.05);三酰甘油(TG)降低〔OR=1.65,95%CI(1.12,1.98)〕和BMI降低〔OR=0.63,95%CI(0.36,0.81)〕对NAFLD减少模型的影响有统计学意义(P<0.05)。结论 BMI升高是NAFLD的独立危险因素,降低BMI与TG则是减少NAFLD发生的保护性因素,NAFLD患者应平衡膳食,减轻体质量,降低血脂水平。
Objective To investigate the parameters related to metabolic syndrome （MS） in prevalence rate of nonal- coholic fatty liver disease （NAFLD） in physical examination population. Methods A total of 1 367 physical examination sub- jects in 2010 and 2011 were divided, according to NAFLD judgment by abdominal B ultrasound results, into negative （n = 890）, increased （n = 145 ）, positive （ n = 257 ）, decreased （ n = 75 ）. The total detection rate of NAFLD was recorded and the relationship between NAFLD and MS analyzed. Results The total NAFLD detection rate was 24. 3% （332/1 367） in the year of 2010, 29. 4% （402/1 367） in 2011, the difference was significant （χ2 = 18. 514, P 〈0. 05）. There were differences between 4 groups in MS - related parameters except in total cholesterol （TC） in 2011 （P 〈 0. 05 ）. By multivariate analysis re- suits, increased BMI [ OR = 1.48, 95% C1 （ 1.06, 1.74） ] was of significance to influence of increased NAFLD models （P 〈 0. 05） ; Decreased TG [ OR = 1.65, 95% CI （1.12, 1.98） ] and BMI [ OR = 0. 63, 95% CI （0.36, 0. 81） ] were signifi- cant to influence of decreased NAFLD models （ P 〈 0. 05 ）. Conclusion Increased BMI is an independent risk factor for NAFLD, decreased BMI and TG are protective factors. NAFLD patients should have balanced diet, reduce body weight, lower blood lipid level
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第6期605-607,共3页
Chinese General Practice
关键词
非酒精性脂肪肝
代谢综合征X
相关性研究
Non- alcoholic fatty liver
Metabolic syndrome X
Correlation study
