摘要
目的探讨非肥胖2型糖尿病(T2DM)患者发生非酒精性脂肪性肝病(NAFLD)的危险因素。方法选择2011年1月—2012年6月我院内分泌科住院非肥胖T2DM患者188例为研究对象,根据腹部B超检查结果,将未合并NAFLD者92例纳入对照组,合并NAFLD者96例纳入观察组。回顾性分析所有患者的临床资料,分析其危险因素。记录患者的性别、年龄、病程及血压情况,测量其身高、体质量、腰围、臀围,计算体质指数(BMI)及腰臀比;检测其空腹血糖(FPG)、空腹胰岛素(Fins)、C肽、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)水平及餐后2 h血糖;计算胰岛素抵抗指数(HOMA-IR)。结果非肥胖T2DM患者NAFLD发生率为51.1%(96/188),其中男性为51.5%(50/97),女性为50.5%(46/91),两者间差异无统计学意义(χ2=0.019,P>0.05)。两组腰臀比及FPG、TG、HDL水平比较,差异均有统计学意义(P<0.05),性别构成及其他指标比较,差异均无统计学意义(P>0.05)。Logistic回归分析显示,腰臀比〔OR=1.42,95%CI(1.13,1.65)〕、TG〔OR=1.37,95%CI(1.08,1.74)〕及HOMA-IR〔OR=1.01,95%CI(0.98,1.04)〕对Logistic回归方程的影响有统计学意义(P<0.05)。结论非肥胖T2DM患者NAFLD发生率较高,腰臀比增大、TG水平及HOMA-IR增高是非肥胖T2DM患者发生NAFLD的独立危险因素。
Objective To investigate the risk factors of non - alcoholic fatty liver disease （NAFLD） in patients with non -obese type 2 diabetes mellitus （T2DM）. Methods Totally 188 patients with non -obese T2DM who were treated in our hospital from Junuary 2011 to June 2012 were enrolled in this study. These patients were divided into the NAF＇LD group （ n = 96） and non - NAFLD group （ n = 92）. The demographic data, physical examination resuhs, and laboratory findings were recorded and compared between these two groups. Including gender, age, disease course, blood pressure, and fasting plasma glucose （FPG）, glycosylated hemoglobin A （HbA^o）, C -peptide, fasting insulin （Fins）, blood fat and 2 h postprandial blood glu- cose were measured. Body mass index （BMI）, waist- to hip ratio （WHR） and insulin resistance index （HOMA- IR） were calculated, and the results were statistics analysised. Results The incidence of NAFLD was 51.1% （96/188） in our cohort, among whom there were 50 males and 46 females （χ2 = 0. 019, P 〉 0. 05 ）. Comparison of the WHR, FPG, total cholesterol （TG）, and high -density lipoprotein showed significant differences between these two groups （P 〈 0.05 ）. Logistic regression analysis showed that WHR [ OR = 1.42, 95% CI （ 1.13, 1.65 ）], TG [ OR = 1.37, 95% CI （ 1.08, 1.74）], and HOMA - IR [ OR = 1.01, 95% CI （0. 98, 1.04） ] were independently positively associated with the incidence of NAFLD in non - obese T2DM patients （P 〈 0. 05 ）. Conclusion Non - obese T2DM patients are more susceptible to NAFLD, with in- creased WHR, TG, and HOMA - IR being the independent risk factors.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第5期500-502,共3页
Chinese General Practice
关键词
肥胖症
糖尿病
2型
非酒精性脂肪肝
危险因素
Obesity
Diabetes mellitus, type 2
Non - alcoholic fatty liver
Risk factors
