摘要
目的分析乙型肝炎肝硬化患者红细胞参数和血清白细胞介素-6(IL-6)、白细胞介素-17(IL-17)和白细胞介素-18(IL-18)水平,并探讨IL-6、IL-17和IL-18在肝硬化贫血发病机制中的作用。方法检测114例乙型肝炎肝硬化组及30例健康对照组红细胞参数。采用酶联免疫法检测肝硬化组及健康对照组血清IL-6、IL-17和IL-18水平。结果乙型肝炎肝硬化组RBC、Hb和Hct明显低于健康对照组(P<0.05),RDW水平明显高于健康对照组(P<0.05);MCV水平与健康对照组比较差异无统计学意义(P>0.05)。肝硬化组血清IL-6、IL-17和IL-18水平明显高于健康对照组(P<0.05);肝硬化组Hb水平与血清IL-6、IL-17及IL-18水平呈负相关(P<0.01)。结论细胞因子IL-6、IL-17及IL-18在乙型肝炎肝硬化性贫血的发病机制中起着重要作用。
Objective To investigate the RBC parameters and the serum levels of IL-6,lL-17 and IL-18,and further to explore the influence of levels of IL-6,IL 17 and IL-18 on the pathogenesis of anemia in the patients with hepatitis B-related cirrhosis. Methods The RBC parameters were detected in 114 patients with hepatitis B-related cirrhosis and 30 healthy people as control group respectively. And the levels of serum IL-6 ,IL-17 and IL-18 were de- tected with ELISA in both groups. Results The levels of RBC, Hb and Hct were significantly decreased,and RDW were significantly increased in the hepatitis B-related cirrhosis group than those in the healthy control group（P〈0.05）. There was no statistical difference in MCV between the two groups（P〉0.05）. The levels of serum IL-6, IL- 17 and IL-18 in the hepatitis B-related cirrhosis group were significantly increased compared with the healthy control group（P〈0.05）. And there was negative relationship between serum levels of IL-6, IL-17 and IL-18 with the level of Hb in the hepatitis B-related cirrhosis group（P〈0.05）. Conclusion Cytokines IL-6,IL-17 and IL-18 play an impor tant role in the pathogenesis of anemia resulted from hepatitis B-related cirrhosis.
出处
《检验医学与临床》
CAS
2013年第5期526-527,529,共3页
Laboratory Medicine and Clinic
