摘要
目的:探讨经皮穿刺家兔邹、慢性心包炎模型建立的微创方法,并行相关病理学研究。方法:据家兔心包解剖特征,取细针胸骨旁心包腔经皮穿刺,分组定量注入复方化学致炎剂及绿脓杆菌,不同期内开胸对心包、心包腔进行病理观察。结果:取本实验方法,所有家兔在不同期内均制作出急、慢性心包炎模型。结论:经皮细针心包腔穿刺是可靠的入腔微创技术。沿此注入“致炎剂”可建立不同病理类型非开胸家兔心包炎模型。
Objective: Try to find a mini - traumatic way to establish an animal model of acute and chronic pericarditis, and observe the relative pathologic changes. Methods: 20 rabbits were randomly divided into two experimental groups. The pericardia! cavities of all animals were entered with transcotaneous access at parastinal site. The compound chemical materials and Bacillus Pyoeyaneous were injected into the pericardial cavities of rabbits in both groups respectively. These animals were killed in one, two and three weeks. The pericardium, pericardial cavities were observed pathologically. Result: The experimental mode is of acute and chronic pericarditis had been made successfully in all rabbits. Conclusion: It is an effective mini - traumanic method for the establishment of experimental model of acute and chronic pericarditis to take the transcutaneous puncture access without thoracotomy.
出处
《中国医药导刊》
2000年第6期41-42,共2页
Chinese Journal of Medicinal Guide
