摘要
目的 通过比较自身免疫甲状腺疾病(ATD)患者血清中过氧化物酶抗体(TPO-Ab)和甲状腺微粒体抗体(TMAb)水平，探讨测定TPO-Ab的临床价值。方法 采用放射免疫法同步测定200例ATD、50例非ATD、30例健康对照血清中甲状腺过氧化物酶抗体和甲状腺微粒体抗体的浓度。结果 ①ATD患者血清中TPO-Ab浓度显著升高(P＜0.01)。②桥本甲状腺炎患者甲功的变化与体内TPO-Ab浓度有关，可在一定程度上提示ATD的预后。③TPO-Ab浓度的变化与TMAb变化一致(r=0.83,P＜0.01)，但用TPO-Ab作为诊断桥本甲状腺炎的指标较TMAb更具敏感性和特异性(P＜0.01)。结论 测定TPOAb是诊断自身免疫甲状腺疾病敏感、特异的指标。
Objective\ To investigate the clinical application of T PO-Ab by comparing the relationship between TPO-Ab and TMAb in ATD.Metho ds In this study with the method of RIA,we measured the serum level of T PO-Ab and TMAb in 200 ATD patients,50 patients with nonATD and 30 normal controls ,a nd analyzed the relationship of TPO-Ab and TMAb,compared the difference between TP O-Ab and TMAb for diagnosis ATD.Results\ TPO-Ab titer increased in A TD especially in Hashimotos thyroiditis(P＜0.01),at the same time it could infl uence the state of the throid function.A significant positive correlation was fo und between TPOAb and TMAb(r=0.83,P＜0.01),but TPOAb appeared to b e more sensitive and specific for diagnosising Hashimotos thyroiditis than TMA b .Conclusion\ TPOAb is a sensitive and specific stantard for diagno sising ATD.
出处
《西安医科大学学报》
CAS
CSCD
2000年第5期433-436,共4页
Journal of Xi'an Medical University(Chinese)
