摘要
目的 :研究气管内镍钛金属网状内支架生物相容性。方法 :在实验兔气管内放置 30枚网状内支架 ,通过观察其 1周～ 6个月局部组织和全身反应 ,初步评价其生物相容性。结果 :自制镍钛记忆内支架具有局部组织反应较轻 ,局部管腔通肠 ,全身重要脏器无改变 ,植入后记忆合金无腐蚀生锈。结论 :自制镍钛记忆合金具有良好的力学性能和生物相容性 。
? Objective:To study histocompatibility of selfmade stents made of NiTi alloy in rabbits.Methods:To place 30 stents made of NiTi alloy into 30 rabbits trachea through mouth under general anethesia,to observe local tissue reaction from 1 week to 6 months and to try to find pathological changes of main organs of rabbits in the 6 th month.Results:During observation,apart from dyspnea in two rabbits,one died at 3 day and the other died at 6 week after implantation.Autopsy showed the implantation sites were occluded by granulation tissue.All other rabbits were normal and implantation sites were patent.In the first three weeks we could observe acute inflammation at the implantation sites while after 5 weeks we could observe chronic inflammation there.We observed that the structure of epithelial cells tended to be normal by telemicroscope.There are no pathological changes in liver,spleen,kidney,lung,heart and brain tissue.Conclusion:Self expanding stents possess good histocompatibility and have no toxic reaction to whole body and fit to implantation into human body.
出处
《白求恩医科大学学报》
CSCD
2000年第6期656-658,共3页
Journal of Norman Bethune University of Medical Science
关键词
介入放射学
气管
内支架
组织相容性
动物实验
interventional radiology
trachea
stent
histocompatibility
animal experiment
