摘要
目的:研究单胺氧化酶A(MAOA)基因单核苷酸多态性(SNP)与特质怒的关系。方法:根据状态特质愤怒表达量表2(STAXI-2)特质怒得分筛选受试者,经采血、酚-氯仿法提取DNA、PCR-LDR法对MAOA基因上的4个标签单核苷酸多态性(Tag SNP)位点进行基因分型,对相关数据进行统计分析。结果:MAOA基因中4个Tag SNP位点的基因型和等位基因频率在高、低特质怒组间的差异无统计学意义。结论:MAOA基因单核苷酸多态性与国内正常大学生特质怒无显著相关性。
Objective： To investigate the association between single nucleotide polymorphism （SNP） of monoamine oxidase A gene（MAOA） and trait anger（T-Ang）. Method： Healthy college students were investigated with the state-trait anger expression inventory 2（STAXI-2）. Four tag SNP of MAOA were genetic typed by PCR-based ligase detection reaction（PCR- LDR）, then we used the SPSS13.0 software for statistical analysis. Results： There were no significant difference in genotype and allel frequency of the four tag SNP between the high and low trait anger group. Conclusion： There is no significant correlation between MAOA gene single nucleotide polymorphisms and trait-anger of China normal university students.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2013年第3期775-777,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.30772686
No.30973695)~~
